| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418428 |
| ISSN: | 1665-2681 |
| Authors: | van de Putte, Dietje Fransen1 Blom, Renske2 van Soest, Hanneke2 Mundt, Marco2 Verveer, Claudia3 Arends, Joop4 de Knegt, Robert E3 Mauser Bunschoten, Eveline1 van Erpecum, Karel2 |
| Institutions: | 1Van Creveldkliniek, Department of Haematology, Utrecht. Países Bajos 2University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht. Países Bajos 3Erasmus University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam, Zuid Holland. Países Bajos 4University Medical Center Utrecht, Department of Internal Medicine and Infectious Diseases, Utrecht. Países Bajos |
| Year: | 2011 |
| Season: | Oct-Dic |
| Volumen: | 10 |
| Number: | 4 |
| Pages: | 469-476 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Liver stiffness measurement (LSM) using Fibroscan® is an increasingly popular non-invasive method for quantifying liver fibrosis in patients with chronic viral hepatitis. We aimed to explore potential impact of Fibroscan® on clinical management. Material and methods. 133 patients with chronic hepatitis B (HBV, n = 75) or C (HCV, n = 58) underwent Fibroscan® measurement. LSM results were compared with liver biopsy results, ultrasound, and APRI-scores, and the impact of LSM on clinical management was evaluated. Results. LSM results indicated fibrosis stage F0-F1 in 84 patients (63%), F2 in 28 (21%), F3 in 8 (6%), and F4 in 13 patients (10%). Nineteen patients had liver biopsies within one year of LSM. In ten patients, LSM and biopsy showed the same fibrosis stage, in 8 there was one stage difference, and in 1 three stages difference. Ultrasound only showed cirrhosis in three patients, who all exhibited advanced cirrhosis at LSM. There was a statistically significant, but weak correlation between LSM results and APRI scores (r = 0.31, pvalue < 0.001). LSM results changed clinical management in 39% of patients (55 cases): in 15 patients antiviral treatment was indicated, in 21 patients surveillance for hepatocellular carcinoma was indicated, and 19 successfully treated hepatitis C patients could be discharged from clinical follow-up in absence of severe fibrosis or cirrhosis. Conclusion. LSM appears to be a valuable non-invasive tool to manage patients with chronic viral hepatitis in clinical practice |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Cirrosis hepática, Fibrosis hepática, Hepatitis B, Hepatitis C, Ultrasonografía, Biopsia, Hepatitis crónica |
| Keyword: | Gastroenterology, Liver cirrhosis, Liver fibrosis, Hepatitis B, Hepatitis C, Ultrasonography, Biopsy, Chronic hepatitis |
| Full text: | Texto completo (Ver PDF) |
