| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415664 |
| ISSN: | 1665-2681 |
| Authors: | Gaba, Ron C1 Kallwitz, Eric R2 Parvinian, Ahmad1 Bui, James T1 Von Roenn, Natasha M2 Berkes, Jamie L2 Cotler, Scott J2 |
| Institutions: | 1University of Illinois Hospital and Health Sciences System, Department of Radiology, Chicago, Illinois. Estados Unidos de América 2Loyola University Medical Center, Section of Hepatology, Chicago, Illinois. Estados Unidos de América |
| Year: | 2013 |
| Season: | Sep-Oct |
| Volumen: | 12 |
| Number: | 5 |
| Pages: | 766-773 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Imaging surveillance and multidisciplinary conference (MDC) review can potentially improve survival in patients with hepatocellular carcinoma (HCC) by increasing access to liver transplantation. Geographic disparities in donor organ availability may reduce this benefit. This study evaluated the impact of HCC surveillance on use of curative therapies and survival in a region with long transplant waiting times. Material and methods. 167 HCC patients were retrospectively studied. Subjects had an established HCC diagnosis or were diagnosed during hepatology follow-up. Collected data included patient demographics, HCC surveillance and MDC review status, portal hypertension complications, laboratory and radiologic parameters, tumor size, therapeutic interventions, tumor progression, and mortality. The primary outcome measures were use of curative treatments and survival. A Cox-regression model was constructed utilizing factors associated with survival in univariate analysis. Results. 58% of subjects underwent surveillance and MDC review of HCC. These patients were more likely to have received treatment with ablation or resection (16 vs. 3%, P = 0.006) and transplantation (23 vs. 4%, P = 0.001), and were less likely to develop tumor progression (45 vs. 68%, P = 0.005) or metastases (0 vs. 19%, P < 0.001). In multivariate analysis, surveillance and MDC review (P = 0.034, HR 0.520, 95% CI 0.284-0.952), tumor meeting Milan criteria (P < 0.001, HR 0.329, 95% CI 0.178-0.607), curative therapy application (P = 0.048, HR 0.130, 95% CI 0.017-0.979), and transplantation (P = 0.004, HR 0.236, 95% CI 0.088-0.632) were associated with survival. Conclusion. In conclusion, imaging surveillance and MDC review is associated with detection of early stage HCC, increased access to curative therapies and transplantation, and prolonged survival |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Oncología, Terapéutica y rehabilitación, Carcinoma hepatocelular, Trasplante de hígado, Seguimiento |
| Keyword: | Medicine, Gastroenterology, Oncology, Therapeutics and rehabilitation, Hepatocellular carcinoma, Liver transplantation, Follow up |
| Full text: | Texto completo (Ver PDF) |
