| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000411821 |
| ISSN: | 1665-2681 |
| Authors: | Origa, Raffaella1 Marceddu, Giuseppe1 Danjou, Fabrice1 Perseu, Luciana2 Satta, Stefania1 Demartis, Franca Rosa1 Piga, Antonio3 Longo, Filomena3 Lai, Maria Eliana1 Vacquer, Stefania1 Galanello, Renzo1 |
| Institutions: | 1Ospedale Regionale per le Microcitemie, Cagliari, Cerdeña. Italia 2Istituto di Ricerca Genetica e Biomedica, Cagliari, Cerdeña. Italia 3Universita di Torino, Thalassemia Center, Orbassano, Piamonte. Italia |
| Year: | 2015 |
| Season: | May-Jun |
| Volumen: | 14 |
| Number: | 3 |
| Pages: | 389-395 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Genome-wide association studies have identified host genetic variation to be critical for spontaneous clearance and treatment response in patients infected with hepatitis C virus. Recently, the role of the IFNL3 polymorphisms in influencing the spontaneous clearance of HCV, the response to interferon and the progression of liver fibrosis, was also demonstrated in patients with thalassemia major infected by genotype 1b. In the present study we retrospectively analyzed 368 anti-HCV positive patients with beta-thalassemia at two Italian major centers in Cagliari and Torino. Results. C/C variant of polymorphism rs12979860 was related to response to interferon treatment and, above all, to spontaneous clearance of the virus. However, the positive predictive power was stronger for viral persistence than spontaneous clearance and in such respect the TT allele was more predictive than CC. The methylation associated polymorphism rs4803221 had independent effects with respect to rs12979860 and the haplotype tagged by SNP rs12979860 and rs4803221 significantly could improve the viral clearance prediction in infected patients. Neither necroinflammation or bilirubin values in the chronic phase of the hepatitis C were related to IFNL3 polymorphisms. No relation among IFNL3 polymorphisms and fibrosis stage directly shown by the liver biopsy was found. Conclusions. Also in thalassemia the SNPs on chromosome 19q13 closely associates with spontaneous and treatment-induced HCV clearance. The viral clearance prediction is significantly improved by the haplotype tagged by SNP rs12979860 and rs4803221. Neither necroinflammation, bilirubin values or fibrosis stage seem to be related to IFNL3 polymorphisms |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Hematología, Genética, Polimorfismo genético, Interleucina, Virus de la hepatitis C, Betatalasemia, Persistencia viral, Eliminación viral |
| Keyword: | Medicine, Gastroenterology, Hematology, Genetics, Genetic polymorphism, Interleukin, Hepatitis C virus, Beta-thalassemia, Viral persistence, Viral clearance |
| Full text: | Texto completo (Ver PDF) |
