| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415679 |
| ISSN: | 1665-2681 |
| Authors: | Ji, Hui-Fan1 Wang, Juan1 Yu, Lei3 Niu, Jun-Qi2 Admassu Ayana, Desalegn4 Jiang, Yan-Fang1 |
| Institutions: | 1Jilin University, Second Part of First Hospital, Changchun, Jilin. China 2Jilin University, First Hospital, Changchun, Jilin. China 3Harbin Medical University, Fourth Hospital of, Harbin, Heilongjiang. China 4Haramaya University, Department of Medical Laboratory Sciences, Harar. Etiopía |
| Year: | 2013 |
| Season: | Jul-Ago |
| Volumen: | 12 |
| Number: | 4 |
| Pages: | 371-379 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | During the early phases of a hepatitis C virus (HCV) infection, NK cell activation appears to be critical to the induction of adaptive immune responses that have the potential of clearing the infection. This study aimed to investigate the phenotype and function of NK cells in chronic HCV (CHC) patients, particularly patients who cleared HCV infections spontaneously (SR-HCV). Material and methods. Peripheral blood NK cells were compared between 36 CHC patients, 12 SR-HCV patients, and 14 healthy controls (HC). The phenotype and function of NK cells were characterized by flow cytometry. In addition, the potential associations between the frequency of NK cell subsets and ALT, AST and HCV viral loads were also analyzed. Results. Our data revealed that the population of CD3-CD56+ NK cells was significantly decreased in CHC and SR-HCV patients compared to levels in HC (P = 0.031, P = 0.014). Interestingly, we found that the levels of the CD158b inhibitory receptor were higher in CHC patients compared to levels observed in HC and SR-HCV subjects (P = 0.018, P = 0.036). In addition, the percentages of the activation receptors NKp30 and NKp46 were significantly decreased in CHC and SR-HCV patients compared to their expression levels in HC (P < 0.05). Moreover, the frequencies of inducible CD107a (but not IFN-γ-secreting) NK cells from both CHC and SR-HCV patients were significantly lower than frequencies observed in controls (P = 0.018, P = 0.027). Conclusion. Our data indicated that the higher frequency of inhibitory NK cells combined with fewer activated NK cells may be associated with HCV-related chronic inflammation involved in CHC pathogenesis |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Virus de la hepatitis C, Hepatitis crónica, Activación celular, Células NK, Marcadores bioquímicos |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Hepatitis C virus, Chronic hepatitis, Cell activation, NK cells, Biochemical markers |
| Full text: | Texto completo (Ver PDF) |
