Herb induced liver injury presumably caused by black cohosh: A survey of initially purported cases and herbal quality specifications
Document title: Herb induced liver injury presumably caused by black cohosh: A survey of initially purported cases and herbal quality specifications
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000418475
ISSN: 1665-2681
Authors: 1
1
1
1
1
Institutions: 1Teaching Hospital of the Goethe University, Klinikum Hanau, Frankfurt, Hessen. Alemania
Year:
Season: Jul-Sep
Volumen: 10
Number: 3
Pages: 249-259
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Herb induced liver injury (HILI) is a particular challenge that also applies to purported cases presumably caused by black cohosh (BC), an herb commonly used to treat menopausal symptoms. We analyzed and reviewed all published case reports and spontaneous reports of initially alleged BC hepatotoxicity regarding quality of case details and causality assessments. Shortcomings of data quality were more evident in spontaneous reports of regulatory agencies compared to published case reports, but assessments with the scale of CIOMS (Council for the International Organizations of Sciences) or its updated version revealed lack of causality for BC in all cases. The applied causality methods are structured, quantitative, and liver specific with clear preference over an ad hoc causality method or the liver unspecific Naranjo scale. Reviewing the case data and the reports dealing with quality specifications of herbal BC products, there is general lack of analysis with respect to authentication of BC in the BC products used by the patients. However, in one single regulatory study, there was a problem of BC authentication in the analysed BC products, and other reports addressed the question of impurities and adulterants in a few BC products. It is concluded that the use of BC may not exert an overt hepatotoxicity risk, but quality problems in a few BC products were evident that require additional regulatory quality specifications
Disciplines: Medicina,
Biología,
Química
Keyword: Gastroenterología,
Farmacología,
Angiospermas,
Plantas medicinales,
Hepatotoxicidad,
Lesión hepática,
Cimífuga,
Actaea cimicifuga,
Ranunculaceae
Keyword: Gastroenterology,
Pharmacology,
Angiosperms,
Medicinal plants,
Hepatotoxicity,
Liver injury,
Black cohosh,
Actaea cimicifuga,
Ranunculaceae
Full text: Texto completo (Ver PDF)