| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418440 |
| ISSN: | 1665-2681 |
| Authors: | Marques, Camila1 Mauriz, José L3 Simonetto, Douglas2 Marroni, Claudio A2 Tuñon, María J3 González Gallego, Javier3 Marroni, Norma P1 |
| Institutions: | 1Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil 3Universidad de León, Instituto de Biomedicina, León, Castilla y León. España |
| Year: | 2011 |
| Season: | Oct-Dic |
| Volumen: | 10 |
| Number: | 4 |
| Pages: | 531-539 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Portal hypertension (PHI) is a clinical syndrome characterized by increases of the blood flow and/or of the vascular resistance in the portal system. A direct consequence of PHI can appearance different lesions on the gastric mucosa and submucosa, cumulatively termed portal hypertensive gastropathy (PHG). Aims. To investigate the effects of glutamine on oxidative stress in an experimental model of PHG induced by partial portal vein ligation (PPVL). Material and methods. Portal pressure, transaminase and alkaline phosphatase activity were quantified. Gastric tissue damage was assessed by histological analysis. Oxidative stress was measured by quantification of cytosolic concentration of thiobarbituric acid reactive substances (TBARS), hydroperoxide-initiated chemiluminescence (QL), and nitric oxide (NO) production. Moreover, activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were analyzed. Results. Transaminase and alkaline phosphatase activities were not significantly modified by PPVL, indicating absence of liver injury. Histological analysis of gastric sections showed a lost of normal architecture, with edema and vasodilatation. TBARS, QL, and NO production were significantly increased in PPVL animals. A reduction of SOD activity was found. Glutamine administration markedly alleviated histological abnormalities and oxidative stress, normalized SOD activity, and blocked NO overproduction. Conclusions. Our results confirm that the use of molecules with antioxidant capacity can provide protection of the gastric tissue in portal hypertension. Glutamine treatment can be useful to reduce the oxidative damage induced by PHI on gastric tissue |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Farmacología, Medicina experimental, Hipertensión portal, Estrés oxidativo, Glutamina, Oxido nítrico, Modelos animales |
| Keyword: | Gastroenterology, Pharmacology, Experimental medicine, Portal hypertension, Oxidative stress, Glutamine, Nitric oxide, Animal models |
| Full text: | Texto completo (Ver PDF) |
