Journal: | Annals of hepatology |
Database: | PERIÓDICA |
System number: | 000417013 |
ISSN: | 1665-2681 |
Authors: | Gutiérrez Cirlos, Carlos1 Ordóñez Sánchez, María Luisa2 Tusié Luna, María Teresa3 Patterson, Bruce W4 Schonfeld, Gustav4 Aguilar Salinas, Carlos A2 |
Institutions: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicina Interna, México, Distrito Federal. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Endocrinología y Metabolismo, México, Distrito Federal. México 3Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, México, Distrito Federal. México 4Washington University, School of Medicine, Saint Louis, Missouri. Estados Unidos de América |
Year: | 2011 |
Season: | Abr-Jun |
Volumen: | 10 |
Number: | 2 |
Pages: | 155-164 |
Country: | México |
Language: | Inglés |
Document type: | Artículo |
Approach: | Analítico, descriptivo |
English abstract | Familial hypobetalipoproteinemia (FHBL) is an autosomal dominant disease characterized by abnormally low levels of apolipoprotein-B (apoB) containing lipoproteins. FHBL is caused by APOB, PCSK9 or ANGPTL3 mutations or is associated with loci located in chromosomes 10 and 3p21. However, other genes should be involved. This study describes the kinetic parameters of the apoB containing lipoproteins and sequence abnormalities of the APOB and PCSK9 genes of FHBL patients identified in a large hospital based survey. Material and methods. Cases with primary or secondary causes of hypobetalipoproteinemia were identified. ApoB kinetics were measured in cases with primary forms in whom truncated forms of apoB were not present in VLDL (n = 4). A primed constant infusion of [13C] leucine was administered, VLDL and LDL apoB production and catabolic rates measured by a multicompartmental model and compared to normolipemic controls. In addition, these subjects had an abdominal ultrasound and direct sequencing was carried out for the PCSK9 and apoB genes. Results. Three individuals had normal apoB production with increased catabolic rate; the remaining had reduced synthetic and catabolic rates. Various polymorphisms, some of them previously unreported (*), in the PCSK9 gene (R46L, A53V, I474V, D480N*, E498K*) and in the apoB gene (N441D*, Y1395C, P2712L, D2285E*, I2286V, T3540S*, T3799M*) were found in the FHBL patients. We found hepatic ultrasound changes of hepatic steatosis in only one of the four probands. Conclusion. FHBL without truncated apoB is a heterogeneous disease from a metabolic and a genetic perspective. Hypobetalipoproteinemia is a risk factor but not an obligate cause of steatosis |
Disciplines: | Medicina |
Keyword: | Gastroenterología, Metabolismo y nutrición, Genética, Hipobetalipoproteinemia, Hipercolesterolemia, Hígado graso no alcohólico, Enfermedades autosómicas dominantes |
Keyword: | Gastroenterology, Metabolism and nutrition, Genetics, Hypobetalipoproteinemia, Hypercholesterolemia, Non alcoholic fatty liver, Autosomal dominant diseases |
Full text: | Texto completo (Ver PDF) |