| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000391016 |
| ISSN: | 1665-2681 |
| Authors: | Kathemann, Simone1 Bechmann, Lars P1 Sowa, Jan-Peter1 Manka, Paul1 Dechene, Alexander1 Gerner, Patrick1 Lainka, Elke1 Hoyer, Peter F1 Feldstein, Ariel E2 Canbay, Ali1 |
| Institutions: | 1University of Duisburg-Essen, Essen, Nordrhein-Westfalen. Alemania 2University of California, Department of Pediactrics, San Diego, California. Estados Unidos de América |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 14 |
| Number: | 5 |
| Pages: | 722-728 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Caso clínico |
| English abstract | Pediatric acute liver failure (PALF) is a progressive, potentially fatal clinical syndrome occurring in previously healthy children. Our study aimed to determine the current leading causes of PALF in a single center in Germany, identifying possible prognostic markers. Thirty-seven pediatric patients with PALF were included. Medical records were reviewed for demographic, laboratory and clinical data. Laboratory results on admission and at peak value, PELD and MELD score on admission, and intensive care support were assessed. Fifteen patients recovered spontaneously, 14 died without transplantation, and 8 received a liver transplant. Patients who survived were significantly older than patients who died. Specific causes of PALF could be identified as infectious diseases (16%), metabolic diseases (14%), toxic liver injury (11%), immunologic diseases (8%), or vascular diseases (8%). Causes of PALF remained indeterminate in 43%. High ammonia, low albumin, and low ALT levels on admission were associated with worse outcome. Absence of need of ventilation, hemodialysis, and circulatory support predicted spontaneous recovery. In conclusion, infections are the most common known cause of PALF. However, in a large proportion of patients the cause for PALF remains cryptic. Ammonia and albumin levels may be of prognostic value to predict outcomes |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Insuficiencia hepática aguda, Amoníaco, Niños, Etiología, Pronóstico |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Acute liver failure, Ammonia, Children, Etiology, Prognosis |
| Full text: | Texto completo (Ver PDF) |
