| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000417011 |
| ISSN: | 1665-2681 |
| Authors: | Drastich, Pavel1 Lata, Jan2 Petrtyl, Jaromir3 Bruha, Radan3 Prochazka, Vlastimil4 Vanasek, Tomas5 Zdenek, Petr6 Skibova, Jelena7 Hucl, Tomas1 Spicak, Julius1 |
| Institutions: | 1Institute for Clinical and Experimental Medicine, Department of Hepatogastroenterology, Praga. República Checa 2Masaryk University, Faculty of Medicine, Brno, Jihomoravsky. República Checa 3Charles University, First Faculty of Medicine, Praga. República Checa 4Palacky University, Faculty of Medicine and Dentistry, Olomouc. República Checa 5Charles University, Faculty of Medicine, Hradec Kralove. República Checa 6Charles University, Plzen. República Checa 7Institute for Clinical and Experimental Medicine, Department of Statistics, Praga. República Checa |
| Year: | 2011 |
| Season: | Abr-Jun |
| Volumen: | 10 |
| Number: | 2 |
| Pages: | 142-149 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Administration of nonselective beta-blockers in prophylaxis of first variceal bleeding is not suitable for all patients. Thus, we evaluated endoscopic variceal band ligation (EVBL) in primary prevention of bleeding in patients with cirrhosis and large esophageal varices. A total of 73 consecutive patients with liver cirrhosis and large esophageal varices without a history of gastrointestinal bleeding were randomized to receive either EVBL or propranolol and were followed for up to 18 months. Forty patients underwent EVBL and 33 patients received propranolol. Variceal bleeding occurred in 2 patients in the EVBL (5%) and in 2 patients in the propranolol group (6%, NS). The 18 month actuarial risk for first variceal bleed was 5% in the EVBL (95% CI, 0-12%) and 20% in the propranolol group (95% CI, 0-49%, NS). The actuarial probability of death at 18 months of follow-up was 5% (95% CI, 0-11%) in the EVBL group and 7% (95% CI, 0-17%, NS) in the propranolol arm. In conclusion, EVBL was an effective and safe alternative to propranolol in primary prophylaxis of bleeding in patients with large esophageal varices |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Sistema cardiovascular, Terapéutica y rehabilitación, Cirrosis hepática, Várices esofágicas, Sangrado variceal, Profilaxis, Ligadura endoscópica, Beta bloqueadores |
| Keyword: | Gastroenterology, Cardiovascular system, Therapeutics and rehabilitation, Liver cirrhosis, Esophageal varices, Variceal bleeding, Prophylaxis, Endoscopic clipping, Beta blockers |
| Full text: | Texto completo (Ver PDF) |
