| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407205 |
| ISSN: | 1665-2681 |
| Authors: | Parízek, Antonín1 Simjak, Patrik1 Cerny, Andrej1 Sestinova, Alena1 Zdenkova, Anna1 Hill, Martin2 Duskova, Michaela2 Prochazka, Martin3 Vlk, Radovan4 Kokrdova, Zuzana5 Koucky, Michal1 Vítek, Libor1 |
| Institutions: | 1Charles University, 1st Faculty of Medicine, Praga. República Checa 2Charles University, Institute of Endocrinology, Praga. República Checa 3Palacky University Olomouc, Medical Faculty, Olomouc. República Checa 4Charles University, 2nd Faculty of Medicine, Praga. República Checa 5Regional Hospital Pardubice, Department of Obstetrics and Gynaecology, Pardubice. República Checa |
| Year: | 2016 |
| Season: | Sep-Oct |
| Volumen: | 15 |
| Number: | 5 |
| Pages: | 757-761 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. Material and methods. methods. Our methods. retrospective multicentric study was performed on 191 consecutive pregnant women with ICP treated with UDCA. Any maternal and/or fetal complications of the UDCA treatment were searched for; healthy pregnant women (n = 256) served as controls. Results. Results. The Results. UDCA treatment improved liver disease status in the majority of the affected women (86.1%). This treatment was well tolerated, with only negligible skin reactions (0.5%) and mild diarrhea (4.7%). No complications attributable to UDCA treatment were detected during the fetal life, delivery, or the early neonatal period. Conclusion. Conclusion. We Conclusion. confirmed the good efficacy and safety of UDCA treatment in pregnancy for both mothers and fetuses/neonates |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Ginecología y obstetricia, Embarazo, Colestasis intrahepática, Complicaciones fetales, Acido ursodeoxicólico |
| Keyword: | Medicine, Gastroenterology, Gynecology and obstetrics, Pharmacology, Pregnancy, Intrahepatic cholestasis, Fetal complications, Ursodeoxycholic acid |
| Full text: | Texto completo (Ver PDF) |
