| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000411633 |
| ISSN: | 1665-2681 |
| Authors: | Singh, Siddharth1 Venkatesh, Sudhakar K2 Keaveny, Andrew3 Keaveny, Sharon4 Miller, Frank H4 Asbach, Patrick5 Godfrey, Edmund M6 Silva, Alvin C2 Wang, Zhen7 Hassan Murad, Mohammad7 Asrani, Sumeet K8 Lomas, David J6 Ehman, Richard L2 |
| Institutions: | 1Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, Minnesota. Estados Unidos de América 2Mayo Clinic, Department of Radiology, Rochester, Minnesota. Estados Unidos de América 3Mayo Clinic, Department of Transplant Surgery, Jacksonville, Florida. Estados Unidos de América 4Northwestern University Feinberg, School of Medicine, Chicago, Illinois. Estados Unidos de América 5Charite Universitatsmedizin Berlin, Department of Radiology, Berlín. Alemania 6Addenbrooke's Hospital, Department of Radiology, Cambridge, Cambridgeshire. Reino Unido 7Mayo Clinic, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Rochester, Minnesota. Estados Unidos de América 8Baylor University Medical Center, Division of Hepatology, Dallas, Texas. Estados Unidos de América |
| Year: | 2016 |
| Season: | May-Jun |
| Volumen: | 15 |
| Number: | 3 |
| Pages: | 363-376 |
| Country: | México |
| Language: | Inglés |
| Document type: | Revisión bibliográfica |
| Approach: | Analítico |
| English abstract | We Background and aims. conducted an individual participant data (IPD) pooled analysis on the diagnostic accuracy of magnetic resonance elastography (MRE) to detect fibrosis stage in liver transplant recipients. Material and methods. Material and methods. Through a systematic literature search, we identified studies on diagnostic performance of MRE for staging liver fibrosis, using liver biopsy as gold standard. We contacted study authors for published and unpublished IPD on age, sex, body mass index, liver stiffness, fibrosis stage, degree of inflammation and interval between MRE and biopsy; from these we limited analysis to patients who had undergone liver transplantation. Through pooled analysis using nonparametric two-stage receiver-operating curve (ROC) regression models, we calculated the cluster-adjusted AUROC, sensitivity and specificity of MRE for any (≥ stage 1), significant (≥ stage 2) and advanced fibrosis (≥ stage 3) and cirrhosis (stage 4). Results. Results. We Results. included 6 cohorts (4 published and 2 unpublished series) reporting on 141 liver transplant recipients (mean age, 57 years; 75.2% male; mean BMI, 27.1 kg/m2 ). Fibrosis stage distribution stage 0, 1, 2, 3, or 4, was 37.6%, 23.4%, 24.8%, 12% and 2.2%, respectively. Mean AUROC values (and 95% confidence intervals) for diagnosis of any (≥ stage 1), significant (≥ stage 2), or advanced fibrosis (≥ stage 3) and cirrhosis were 0.73 (0.66-0.81), 0.69 (0.62-0.74), 0.83 (0.61-0.88) and 0.96 (0.93-0.98), respectively. Similar diagnostic performance was observed in stratified analysis based on sex, obesity and inflammation grade. Conclusions. Conclusions. In Conclusions. conclusion, MRE has high diagnostic accuracy for detection of advanced fibrosis and cirrhosis in liver transplant recipients, independent of BMI and degree of inflammation |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Fibrosis, Elastografía, Métodos no invasivos, Trasplantes, Hígado, Biomarcadores |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Pharmacology, Fibrosis, Elastography, Non-invasive methods, Transplantation, Liver, Biomarkers |
| Full text: | Texto completo (Ver PDF) |
