| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000413465 |
| ISSN: | 1665-2681 |
| Authors: | Safi, Wajima1 Rauscher, Isabel1 Umgelter, Andreas1 |
| Institutions: | 1Universitat Munchen, Klinikum rechts der Isar der Technischen, Munich, Baviera. Alemania |
| Year: | 2015 |
| Season: | Nov-Dic |
| Volumen: | 14 |
| Number: | 6 |
| Pages: | 895-901 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The nephrotoxic potential of intravenous iodinated contrast (IC) is controversial. Cirrhotic patients are often submitted to imaging procedures involving IC and small changes in renal function may have detrimental effects. Material and methods. Retrospective analysis of hospitalized patients with elective imaging by either contrast-enhanced CT or MRI. Contrast induced acute kidney injury (CI-AKI) was diagnosed if there was either an increase of SCr by 25% or by 44 μmol/L or a decrease of estimated glomerular filtration rate by 25% by day 3. Results. Between 2004 and 2012 152 patients (female: 30.3%, age: 60 ± 10.8 years, MELD 13 ± 6) were included in this study of which 84 (55.3%) had received IC and 68 (44,7%), who served as controls, MRI with gadolinium based contrast (non-IC). Baseline paremeters were well matched except for age (61.7 vs. 56.9) years in the IC vs. non-IC groups, p = 0.005). 15 patients (17.9%) receiving IC and 4 patients (5.9%) not receiving IC (p = 0.026) reached the composite end-point for CI-AKI. In multivariable regression analysis INR [B = 0.252 (95% CI: 0.108-0.397), p = 0.001]; IC [B = 0.136 (95% CI: 0.023-0.248), p = 0.019] and serum sodium [B = 0.011 (95% CI: 0.001-0.023); p = 0.080] were independently associated with changes of SCr. In conclusion IC may cause renal dysfunction in cirrhotic patients. Patients subjected to imaging using IC should be closely monitored |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Farmacología, Gastroenterología, Cirrosis hepática, Medios de contraste, Tomografía computarizada, Efectos adversos, Lesión renal aguda |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Pharmacology, Liver cirrhosis, Contrast media, Computed tomography, Adverse effects, Acute kidney injury |
| Full text: | Texto completo (Ver PDF) |
