| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000419054 |
| ISSN: | 1665-2681 |
| Authors: | MacKinney Novelo, Ileana1 Barahona Garrido, Josué2 Castillo Albarran, Fátima1 Santiago Hernández, Jean J1 Méndez Sánchez, Nahum1 Uribe, Misael1 Chávez Tapia, Norberto1 |
| Institutions: | 1Fundación Clínica Médica Sur, Unidad de Obesidad y Enfermedades Digestivas, México, Distrito Federal. México 2Grupo Hospitalario Guatemala, Hospital Las Américas, Ciudad de Guatemala. Guatemala |
| Year: | 2012 |
| Season: | Sep-Oct |
| Volumen: | 11 |
| Number: | 5 |
| Pages: | 652-657 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Hepatitis A is the most common type of viral hepatitis in Mexico. The change of hepatitis A epidemiology in Mexico from high to intermediate endemicity leads to increasing susceptible adults for severe illness. Objective. To describe the clinical characteristics and hospital outcome of adult patients with acute hepatitis A infection, and determine risk factor for mortality. Material and methods. This is a retrospective observational, multicentre study in Mexico City and in Guatemala City. All inhospital patients were followed until discharge or death. Risk factors for death/acute liver failure were identified. Results. Forty seven patients were analyzed, sixty percent were male, the prodrome phase was from 3 to 30 days. The three most common symptoms were fever, malaise and jaundice, with 87%, 74% and 62% respectively. The incidence of patients who were treated with antibiotics before hospital admission was up to 34%. Unnecessary imaging studies and out of guidelines drugs were used. Presence of encephalopathy, leukocytes > 19,000/mL, blood urea nitrogen > 36 mg/dL, creatinine > 2 mg/dL, albumin < 2.5 mg/dL and total bilirubin > 9.6 mg/dL, are predictors of mortality. Serum creatinine > 2 mg/dL has the best sensibility and specificity for predicting fulminant hepatitis/death. Conclusion. Acute hepatitis A infection in adults is associated some unnecessary diagnostic and therapeutic approach. Could be associated with fulminant hepatitis, and a creatinine value > 2 mg/dL is the best predictor for fulminant hepatitis and death |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Hepatitis A, Falla hepática aguda, Factores de riesgo, Mortalidad |
| Keyword: | Gastroenterology, Hepatitis A, Acute liver failure, Risk factors, Mortality |
| Full text: | Texto completo (Ver PDF) |
