| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000416616 |
| ISSN: | 1665-2681 |
| Authors: | Carvalho, Grazielle Cerqueira de1 Regis, Catarina de Andrade1 Kalil, Jamile Rosario1 Cerqueira, Liv Aparicio1 Barbosa, Daniel Silva1 Motta, Marina Pamponet1 Nery, Marilia da Silva1 Soares, Maria Alice Pires1 Zollinger, Claudio Celestino1 Bittencourt, Paulo Lisboa1 |
| Institutions: | 1Hospital Portugues de Salvador, Unidade de Gastroenterologia e Hepatologia, Salvador, Bahia. Brasil |
| Year: | 2012 |
| Season: | Ene-Feb |
| Volumen: | 11 |
| Number: | 1 |
| Pages: | 90-95 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Renal failure (RF) is reported to occur in 11-49% of the patients with decompensated end-stage liver disease (ESLD) and has been associated with increased mortality, particularly in the occurrence of hepatorenal syndrome (HRS) type 1. Aims. To evaluate the frequency and outcome of RF in patients admitted to the hospital due to decompensated ESLD and to assess the impact of the underlying cause of RF on survival. Material and methods. Four hundred and six patients (65% males, mean age 62 ± 12 years) with decompensated ESLD were evaluated for the occurrence of RF (defined as serum creatinine ³ 1.5 mg/mL). The underlying cause of RF was reckoned in each subject and compared to outcome. Results. Renal failure was observed in 39% of the patients at admission and in 10% of the subjects during hospitalization. Mortality was significantly higher in subjects with RF (26 vs. 1%, p < 0.000001). Hypovolemia, bacterial infections, parenchymal kidney diseases and HRS were identified as causes of RF in, respectively, 40, 32, 15 and 12% of the cases. Mortality was significantly higher in those subjects with HRS type 1 and bacterial infections, when compared to other causes of RF. Conclusions. Renal failure occurs in nearly half of the patients with decompensated ESLD. It is most commonly caused by hypovolemia and bacterial infections. Occurrence of RF has an adverse impact in patient survival, particularly in those subjects with bacterial infections and HRS type 1, prone to develop progressive renal dysfunction despite intensive medical care |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Nefrología, Cirrosis hepática, Síndrome hepatorrenal, Infecciones bacterianas, Falla renal, Mortalidad |
| Keyword: | Gastroenterology, Nephrology, Liver cirrhosis, Hepatorenal syndrome, Bacterial infections, Renal failure, Mortality |
| Full text: | Texto completo (Ver PDF) |
