| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000413408 |
| ISSN: | 1665-2681 |
| Authors: | Kliemann, Dimas A1 Wolff, Fernando H2 Tovo, Cristiane V1 Alencastro, Paulo R3 Ikeda, Maria L.R3 Brandao, Ajacio B.M1 Barcellos, Nemora3 Fuchs, Sandra C2 |
| Institutions: | 1Universidade Federal de Ciencias da Saude de Porto Alegre, Escola de Medicina, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Rio Grande do Sul. Brasil 3Sanatorio Partenon, Servico de Atencao Terapeutica, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2016 |
| Season: | Ene-Feb |
| Volumen: | 15 |
| Number: | 1 |
| Pages: | 27-32 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Liver biopsy has been considered the gold standard for the diagnosis and quantification of fibrosis. However, this method presents limitations. In addition, the non-invasive evaluation of liver fibrosis is a challenge. The aim of this study was to validate the fibrosis cirrhosis index (FCI) index in a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients, and compare to AST/ALT ratio (AAR), AST to platelet ratio index (APRI) and FIB-4 scores, as a tool for the assessment of liver fibrosis in coinfected patients. Material and methods. Material and methods. Material and methods. Retrospective cross sectional study including 92 HIV-HCV coinfected patients evaluated in two reference centers for HIV treatment in the Public Health System in Southern Brazil. Patients who underwent liver biopsy for any indication and had concomitant laboratory data in the 3 months prior to liver biopsy, to allow the calculation of studied noninvasive markers (AAR, APRI, FIB-4 and FCI) were included. Results. Results. APRI Results. < 0.5 presents the higher specificity to detect no or minimal fibrosis, whereas APRI > 1.5 presents the best negative predictive value and FCI > 1.25 the best specificity to detect significant fibrosis. The values of noninvasive markers for each Metavir fibrosis stage showed statistically significant differences only for APRI. In conclusion, until better noninvasive markers for liver fibrosis are developed and validated for HIV-HCV coinfected patients, noninvasive serum markers should be used carefully in this population |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Coinfecciones, Virus de la hepatitis C, VIH, Fibrosis hepática, Diagnóstico no invasivo |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Coinfections, Hepatitis C virus, HIV, Liver fibrosis, Non invasive diagnosis |
| Full text: | Texto completo (Ver PDF) |
