| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415680 |
| ISSN: | 1665-2681 |
| Authors: | Genc, Halil1 Dogru, Teoman1 Kara, Muammer1 Tapan, Serkan2 Ercin, Cemal Nuri1 Acikel, Cengizhan3 Karslioglu, Yildirim4 Bagci, Sait1 |
| Institutions: | 1Gulhane School of Medicine, Department of Gastroenterology, Ankara. Turquía 2Gulhane School of Medicine, Department of Medical Biochemistry, Ankara. Turquía 3Gulhane School of Medicine, Department of Epidemiology, Ankara. Turquía 4Gulhane School of Medicine, Department of Pathology, Ankara. Turquía |
| Year: | 2013 |
| Season: | Jul-Ago |
| Volumen: | 12 |
| Number: | 4 |
| Pages: | 380-387 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Visfatin is a proinflammatory and insulin-mimetic adipokine contributing to whole body glucose and lipid metabolism. Studies to date are conflicting regarding the relationship between visfatin and non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the relationship of circulating visfatin with NAFLD. Material and methods. The study included 114 NAFLD patients and 60 healthy non-diabetic controls. Plasma visfatin, adiponectin, tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) levels were measured by ELISA. High sensitive C-reactive protein (hsCRP) levels were measured by immunoturbidimetric fixed rate method. Insulin sensitivity determined by homeostasis model assessment (HOMA-IR) index. Results. TNF-α, IL-6 and hsCRP levels were higher and, Adiponectin levels were lower in NAFLD group when compared to healthy controls (p < 0.001, for all). However, no difference was found regarding to visfatin levels between two groups. Different histologic subgroups of NAFLD had a significantly higher TNF-α, IL-6 and hsCRP, and lower adiponectin levels than those with controls (p < 0.001, for all). On the other hand, no statistically significant difference was found regarding to visfatin levels among different histologic groups. Visfatin was found to be negatively correlated with TNF-α (r = -0.236, p = 0.011) in NAFLD group. However, no association was found between visfatin and histological findings. Conclusion. Our findings show that plasma visfatin levels are not altered in the early stages of NAFLD. However, it is inversely associated with TNF-α. These findings suggest a role for visfatin in protection against liver injury in this widespread disease |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Hígado graso no alcohólico, Visfatina, Plasma, Inflamación sistémica, Adiponectina, Factor de necrosis tumoral, Interleucina-6 |
| Keyword: | Medicine, Gastroenterology, Non alcoholic fatty liver, Visfatin, Plasma, Systemic inflammation, Adiponectin, Tumor necrosis factor, Interleukin-6 |
| Full text: | Texto completo (Ver PDF) |
