| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415630 |
| ISSN: | 1665-2681 |
| Authors: | Gupta, Vinod H1 Singh, Meenakshi2 Amarapurkar, Deepak N3 Sasi, Preetha1 Joshi, Jyotsna M4 Baijal, Rajiv5 Kumar, Praveen H.R5 Amarapurkar, Anjali D6 Joshi, Kalpana7 Wangikar, Pramod P2 |
| Institutions: | 1Indian Institute of Technology Bombay, Department of Biosciences and Bioengineering, Bombay, Maharashtra. India 2Indian Institute of Technology Bombay, Department of Chemical Engineering, Bombay, Maharashtra. India 3Bombay Hospital and Medical Research Centre, Department of Gastroenterology and Hepatology, Bombay, Maharashtra. India 4TN Medical College, Department of Pulmonary Medicine, Bombay, Maharashtra. India 5Jagjivanram Western Railway Hospital, Department of Gastroenterology and Hepatology, Bombay, Maharashtra. India 6TN Medical College, Department of Pathology, Bombay, Maharashtra. India 7Symbiosis School of Biomedical Sciences, Department of Biotechnology, Pune, Maharashtra. India |
| Year: | 2013 |
| Season: | Nov-Dic |
| Volumen: | 12 |
| Number: | 6 |
| Pages: | 959-965 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The first line anti-tubercular (anti-TB) treatment normally involves isoniazid, rifampicin, pyrazinamide, and ethambutol. Clearance of these drugs depends on the activity of several enzymes such as N-acetyl transferase 2, cytochrome P450 oxidase and glutathione S-transferase (GST). Some of these enzymes are highly polymorphic leading to significant inter-individual variation in their activity thereby increasing the risk of drug induced hepatotoxicity (DIH). Aim. To investigate the possible association of anti-TB DIH with genetic polymorphism of GST genes in Western Indian population. Material and methods. A prospective case-control study was undertaken on patients who received anti-TB treatment. Cases (n = 50) were distinguished from controls (n = 246) based on occurrence of DIH during anti-tubercular treatment. A multiplex polymerase chain reaction was employed to identify homozygous null mutation at GSTM1 and GSTT1 loci. Results. Homozygous null mutation in GSTM1 gene alone or in both GSTM1 and T1 genes was found to be significantly associated with anti-TB DIH at p < 0.02 and p < 0.007, respectively, in our study population. Conclusions. This is the first study to report GSTM1 null and combined GSTM1 and T1 null genotypes to be risk factors of anti-TB DIH in Western Indian population. Screening of patients for these genotypes prior to anti-TB regimen would provide better control of hepatotoxicity |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Fármacos antituberculosos, Hepatotoxicidad, Polimorfismo genético |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Antituberculosis agents, Hepatotoxicity, Genetic polymorphism |
| Full text: | Texto completo (Ver PDF) |
