| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000391017 |
| ISSN: | 1665-2681 |
| Authors: | Ramos Lopez, Omar1 Roman, Sonia1 Martinez Lopez, Erika1 Gonzalez Aldaco, Karina1 Ojeda Granados, Claudia1 Sepulveda Villegas, Maricruz1 Panduro, Arturo1 |
| Institutions: | 1Hospital Civil de Guadalajara, Departamento de Biología Molecular, Guadalajara, Jalisco. México |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 14 |
| Number: | 5 |
| Pages: | 729-734 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, analítico |
| English abstract | Alcohol intake has been associated with the bitter taste receptor T2R38. TAS2R38 gene expresses two common haplotypes: PAV and AVI. It has been reported that AVI homozygotes consume more alcohol than heterozygotes and PAV homozygotes. The aim of this study was to determine the prevalence of the TAS2R38 haplotypes among Mexican-Mestizo population and to analyze its association with alcohol intake. Material and methods. In a cross-sectional study, a total of 375 unrelated Mestizo individuals were genotyped for TAS2R38 polymorphisms (A49P, V262A and I296V) by a Real-Time PCR System (TaqMan). Haplotype frequencies were calculated. Association of TAS2R38 haplotypes with alcohol intake was estimated in drinkers (DRS) and nondrinkers (NDRS). Results. Two haplotypes accounted for over 96% of all haplotypes (AVV, 60%, and PAI, 36.5%). The frequency of AVV homozygotes was significantly higher in DRS than NDRS (47.2 vs. 32.2%, respectively; p < 0.05). Additionally, the AVV/AVV genotype was associated with alcohol intake when compared with heterozygotes and PAI homozygotes (OR = 1.79, 95% CI 1.13-2.84, p < 0.05 and OR = 2.23, 95% CI 1.11-4.48; p < 0.05, respectively). Conclusions. In conclusion, two TAS2R38 haplotypes (AVV and PAI) prevailed in Mexican-Mestizo population. The novel AVV haplotype was associated with alcohol intake. The high prevalence of this allelic profile in our population could help to explain, at least in part, the preference for alcohol among the Mexicans |
| Disciplines: | Medicina |
| Keyword: | Genética, Consumo de alcohol, Sabor amargo, Percepción, Haplotipos |
| Keyword: | Medicine, Genetics, Alcohol consumption, Bitter taste, Perception, Haplotypes, Mexico |
| Full text: | Texto completo (Ver PDF) |
