| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407157 |
| ISSN: | 1665-2681 |
| Authors: | Behairy, Behairy E1 El-Araby, Hanaa A1 Abd El kader, Hasan H2 Ehsan, Nermin A1 Salem, Menan E1 Zakaria, Haidy M3 Khedr, Mohammed A1 |
| Institutions: | 1Menofia University, National Liver Institute, Shebeen El-Kom, Menofia. Egipto 2University of Arizona, Health Sciences Center, Tucson, Arizona. Estados Unidos de América 3Ministry of Health, Quesna Central Hospital, Quesna, Menofia. Egipto |
| Year: | 2016 |
| Season: | Sep-Oct |
| Volumen: | 15 |
| Number: | 5 |
| Pages: | 682-690 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | T-cell populations regulate the balance of immune responses. The CD (Cluster of differentiation) 4+CD25+ regulatory T cells (Tregs) are crucial for maintaining negative control of various immune responses. There are different T-cell subpopulations with regulatory functions, as natural killer T cells, CD8+ and CD28. The forkhead box P3 (FOXP3) regulates Treg development and is required for its suppressive function. Aim. To Aim. evaluate the hepatic expression of the intrahepatic Tregs, Ig (immunoglobulin) G and IgM plasma cells in autoimmune hepatitis (AIH) and other chronic liver diseases (CLDs). Material and methods. Material and methods. This study Material and methods. included 100 pediatric patients; 50 AIH and 50 CLDs other than AIH. All patients were subjected to routine investigations of CLDs plus immune-staining of liver tissue for FOXp3, IgG and IgM plasma cells, CD4 and CD8 T-cells. Results. Results. The Results. FOXP3+ T cells in patients with AIH (6.3 ± 5) were significantly higher than that in the non-AIH (2.1 ± 2.6). FOXP3+ T cells were abundant in liver tissue with marked inflammatory cellular infiltrate. CD4+ and CD8+ infiltrating the liver tissue and IgG positive cells were significantly higher in AIH group, while the expression of IgM positive cells showed no significant difference. The IgG/IgM was significantly higher in the AIH treatment responders (3 ± 3) than non-responders (1.6 ± 0.5), while there was no significant difference regarding the intrahepatic expression of FOXP3+, CD4+, CD8+ cells, T-cells, IgG and IgM plasma cells. Conclusion. Conclusion. Conclusion. Intrahepatic Tregs were increased in number in patients with AIH in the initial presentation, and their presence is associated with increased activity and inflammation in liver biopsy |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Pediatría, Inmunología, Hepatitis autoinmune, Inmunoglobulinas, Células T |
| Keyword: | Medicine, Gastroenterology, Pediatrics, Immunology, Autoimmune hepatitis, Immunoglobulins, T cells |
| Full text: | Texto completo (Ver PDF) |
