| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415034 |
| ISSN: | 1665-2681 |
| Authors: | Coppola, Nicola1 Gentile, Ivan2 Pasquale, Giuseppe1 Buonomo, Antonio Riccardo2 Capoluongo, Nicolina1 D’Armiento, Maria3 Borgia, Guglielmo2 Sagnelli, Evangelista1 |
| Institutions: | 1Seconda Universita degli Studi di Napoli, Dipartimento di Sanita Mentale e Sanita Pubblica, Nápoles, Campania. Italia 2Universita di Napoli "Federico II", Dipartimento di Medicina Clinica e Chirurgica, Nápoles, Campania. Italia 3Universita di Napoli "Federico II", Dipartimento per l'Alta Scienza Biomedica, Nápoles, Campania. Italia |
| Year: | 2014 |
| Season: | Ene-Feb |
| Volumen: | 13 |
| Number: | 1 |
| Pages: | 20-26 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | In patients with chronic hepatitis C it is still debated whether previous exposure to the hepatitis B virus, diagnosed from the presence of the anti-HBc antibody, is linked to a greater risk of severe hepatitis. The aim of the study was to evaluate whether the presence of anti-HBc antibodies is associated with cirrhosis in patients with HBsAg-negative chronic hepatitis C. Material and methods. Two hundred twenty-two consecutive HBsAg-negative patients with HCV-related chronic hepatitis were enrolled at their first liver biopsy. Ishak’s scoring system was used to grade necroinflammation and fibrosis and the patients with stage 5 or 6 were considered as having histological cirrhosis. Results. Patients with histological cirrhosis had a higher mean age, AST, ALT, a lower platelet count and prothrombin activity compared to those with milder fibrosis. The presence of anti-HBc was identified in 21 (63.6%) of the 33 patients with fibrosis score 5 or 6 and in 56 (29.6%; p < 0.001) of the 189 with score ≤ 4. Patients with cirrhosis had a significantly higher grading than those without cirrhosis (median = 8, IQR 6-11 vs. Median = 6, IQR = 4-8, respectively, p < 0.001). A multivariate logistic regression analysis showed that age, sex and anti-HBc positivity were independent predictors of histological cirrhosis. Conclusion. Our data support the idea that in patients with chronic hepatitis C the presence in serum of anti-HBc is associated with histological cirrhosis and is therefore a marker of clinical value |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Hepatitis B, Hepatitis C, Hepatitis crónica, Fibrosis hepática, Infecciones virales |
| Keyword: | Medicine, Gastroenterology, Hepatitis B, Hepatitis C, Chronic hepatitis, Liver fibrosis, Viral infections |
| Full text: | Texto completo (Ver PDF) |
