| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415016 |
| ISSN: | 1665-2681 |
| Authors: | Konicková, Renata1 Vankova, Katerina1 Vankova, Jana1 Vanova, Katerina1 Muchova, Lucie1 Subhanova, Iva1 Zadinova, Marie1 Zelenka, Jaroslav2 Dvorak, Ales1 Kolar, Michal3 Strnad, Hynek3 Rimpelova, Silvie4 Ruml, Tomas4 Wong, Ronald J5 Vítek, Libor1 |
| Institutions: | 1Charles University, First Faculty of Medicine, Praga. República Checa 2Academy of Sciences of the Czech Repubic, Institute of Physiology, Praga. República Checa 3Academy of Sciences of the Czech Republic, Institute of Molecular Genetics, Praga. República Checa 4Institute of Chemical Technology, Department of Biochemistry and Microbiology, Praga. República Checa 5Stanford University, School of Medicine, Stanford, California. Estados Unidos de América |
| Year: | 2014 |
| Season: | Mar-Abr |
| Volumen: | 13 |
| Number: | 2 |
| Pages: | 273-283 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Spirulina platensis is a blue-green alga used as a dietary supplement because of its hypocholesterolemic properties. Among other bioactive substances, it is also rich in tetrapyrrolic compounds closely related to bilirubin molecule, a potent antioxidant and anti-proliferative agent. The aim of our study was to evaluate possible anticancer effects of S. platensis and S. platensis-derived tetrapyrroles using an experimental model of pancreatic cancer. The anti-proliferative effects of S. platensis and its tetrapyrrolic components [phycocyanobilin (PCB) and chlorophyllin, a surrogate molecule for chlorophyll A] were tested on several human pancreatic cancer cell lines and xenotransplanted nude mice. The effects of experimental therapeutics on mitochondrial reactive oxygen species (ROS) production and glutathione redox status were also evaluated. Compared to untreated cells, experimental therapeutics significantly decreased proliferation of human pancreatic cancer cell lines in vitro in a dose-dependent manner (from 0.16 g·L-1 [S. platensis], 60 μM [PCB], and 125 μM [chlorophyllin], p<0.05). The anti-proliferative effects of S. platensis were also shown in vivo, where inhibition of pancreatic cancer growth was evidenced since the third day of treatment (p < 0.05). All tested compounds decreased generation of mitochondrial ROS and glutathione redox status (p = 0.0006; 0.016; and 0.006 for S. platensis, PCB, and chlorophyllin, respectively). In conclusion, S. platensis and its tetrapyrrolic components substantially decreased the proliferation of experimental pancreatic cancer. These data support a chemopreventive role of this edible alga. Furthermore, it seems that dietary supplementation with this alga might enhance systemic pool of tetrapyrroles, known to be higher in subjects with Gilbert syndrome |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Oncología, Algas, Suplementos dietéticos, Algas verde-azules, Ficocianinas, Ficocinaobilina, Bilirrubina, Hemo oxigenasa, Actividad antiproliferativa, Spirulina platensis |
| Keyword: | Medicine, Gastroenterology, Oncology, Pharmacology, Algae, Dietary supplements, Blue-green algae, Phycocyanin, Phycocyanobilin, Bilirubin, Hemo oxygenase, Antiproliferative activity, Spirulina platensis |
| Full text: | Texto completo (Ver PDF) |
