| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418436 |
| ISSN: | 1665-2681 |
| Authors: | Bonacini, Maurizio1 |
| Institutions: | 1California Pacific Medical Center, Department of Transplantation, San Francisco, California. Estados Unidos de América |
| Year: | 2011 |
| Season: | Oct-Dic |
| Volumen: | 10 |
| Number: | 4 |
| Pages: | 502-507 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | To evaluate alcohol use in patients with HIV infection, assess ethnic and social associations, and describe outcomes. Material and methods. Design: cohort study. Setting: Academic HIV-Liver Clinic. Patients: 431 HIV-infected patients (371 men, 60 women); 249 patients with HIV/HCV coinfection, 115 HIV alone, and 67 with HIV/HBV. Intervention: alcohol use was estimated at first interview and reported as the estimated average lifetime consumption in grams/day. Outcome measures: laboratory values, liver fibrosis, decompensation and mortality. Results. Twenty-two percent of patients in the entire cohort had high risk lifetime average alcohol consumption, defined as ≥ 50 mg/day. Fifty-six percent of patients had quit all alcohol when first evaluated, but follow-up showed that 26% continued high risk consumption. By univariate analysis high alcohol consumption was associated with Latino ethnicity, injection drug use (IDU) and hepatitis C (HCV) coinfection. Multivariable analysis showed only IDU to be independently associated with high alcohol consumption (RR = 4.1, p = 0.0005). There were no significant differences in laboratory values, including CD4 cell counts, except for a trend towards higher transaminases and liver fibrosis scores, between high and low alcohol users. All-cause mortality was statistically higher in the high (37%) vs. low (25%, p = 0.03) alcohol use group, and was associated with both IDU (RR = 2.2, p = 0.04) and the amount of alcohol consumed (RR = 1.1, p = 0.04). Liver decompensation and mortality were both higher in the high use group but of borderline significance. Using an ordinal grouping, we found a strong correlation (R = 0.88) between alcohol consumption and the percentage of liver death over total deaths, with lowest mortality rates found in those use of 10 g/day or less. Conclusions. Unsafe use of alcohol is prevalent in HIVinfected patients and stoppage is not universal |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Toxicología, Consumo de alcohol, Infecciones virales, VIH, Virus de la hepatitis B, Virus de la hepatitis C, Seroprevalencia |
| Keyword: | Gastroenterology, Toxicology, Alcohol consumption, Viral infections, HIV, Hepatitis B virus, Hepatitis C virus, Seroprevalence |
| Full text: | Texto completo (Ver PDF) |
