| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415686 |
| ISSN: | 1665-2681 |
| Authors: | Lazzarotto, Cesar1 Ronsoni, Marcelo Fernando1 Fayad, Leonardo1 Nogueira, Christiane Lourenco1 Bazzo, Maria Luiza1 Narciso-Schiavon, Janaina Luz1 Lucca Schiavon, Leonardo de1 Dantas-Correa, Esther Buzaglo1 |
| Institutions: | 1Universidade Federal de Santa Catarina, Hospital Universitario, Florianopolis, Santa Catarina. Brasil |
| Year: | 2013 |
| Season: | Jul-Ago |
| Volumen: | 12 |
| Number: | 4 |
| Pages: | 431-439 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Bacterial infection is a frequent complication in patients with decompensated liver cirrhosis and is related to high mortality rates during follow-up of these individuals. We sought to evaluate the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) in diagnosing infection and to investigate the relationship between these biomarkers and mortality after hospital admission. Material and methods. Prospective study that included cirrhotic patients admitted to the hospital due to complications of the disease. The diagnostic accuracy of CRP and PCT for the diagnosis of infection was evaluated by estimating the sensitivity and specificity and by measuring the area under the receiver operating characteristics curve (AUROC). Results. A total of 64 patients and 81 hospitalizations were analyzed during the study. The mean age was 54.31 ± 11.87 years with male predominance (68.8%). Significantly higher median CRP and PCT levels were observed among infected patients (P < 0.001). The AUROC of CRP and PCT for the diagnosis of infection were 0.835 ± 0.052 and 0.860 ± 0.047, respectively (P = 0.273). CRP levels > 29.5 exhibited sensitivity of 82% and specificity of 81% for the diagnosis of bacterial infection. Similarly, PCT levels > 1.10 showed sensitivity of 67% and specificity of 90%. Significantly higher levels of CRP (P = 0.026) and PCT (P = 0.001) were observed among those who died within three months after admission. Conclusion. CRP and PCT were reliable markers of bacterial infection in subjects admitted due to complications of liver cirrhosis and higher levels of these tests are related to short-term mortality in those patients |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Cirrosis hepática, Infecciones bacterianas, Proteína C reactiva, Procalcitonina, Sobrevivencia |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Liver cirrhosis, Bacterial infections, C reactive protein, Procalcitonin, Survival |
| Full text: | Texto completo (Ver PDF) |
