| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000416325 |
| ISSN: | 1665-2681 |
| Authors: | Brahm, Javier1 Brahm, Magdalena Segovia, Roberto2 Latorre, Ricardo1 Zapata, Rodrigo3 Poniachik, Jaime1 Buckel, Erwin4 Contreras, Luis5 |
| Institutions: | 1Universidad de Chile, Hospital Clínico, Santiago de Chile. Chile 2Clínica Las Condes, Departamento de Gastroenterología, Santiago de Chile. Chile 3Clínica Alemana, Departamento de Gastroenterología, Santiago de Chile. Chile 4Clínica Las Condes, Unidad de Trasplante Hepático, Santiago de Chile. Chile 5Clínica Las Condes, Departamento de Patología, Santiago de Chile. Chile |
| Year: | 2011 |
| Season: | Ene-Mar |
| Volumen: | 10 |
| Number: | 1 |
| Pages: | 93-98 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, descriptivo |
| English abstract | Flutamide is a non-steroidal anti-androgenic drug, commonly used in the treatment of advanced prostate cancer, acne and hirsutism. This drug may induce various degrees of liver injury, including acute liver failure (ALF), with further need for liver transplantation. Here, we present a report of 10 consecutive patients seen in a period of 14 years, with acute liver toxicity induced by flutamide (in most cases severe hepatotoxicity): 3 men and 7 women, with a mean age of 75 and 29 years old, respectively. All men received flutamide as treatment of advanced prostate carcinoma and they developed hepatotoxicity without ALF, and three months after withdrawal of the drug, they recovered completely. In contrast, in 7 young female with liver toxicity caused by flutamide as treatment of various hyperandrogenic conditions (acne and hirsutism), ALF was observed in 5 patients, all of them requiring urgent liver transplantation, with excellent outcome and survival in 4 of them. Based on the above, we believe that flutamide treatment should be preferentially avoided in young female patients with benign pathologies, or if it is used, patients should be warned of its potential severe complications. Also, serial liver tests should be closely monitored and, in case of elevations, the drug should be immediately withdrawn |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Farmacología, Flutamida, Hepatotoxicidad, Hepatitis aguda, Hepatitis fulminante |
| Keyword: | Gastroenterology, Pharmacology, Flutamide, Hepatotoxicity, Acute hepatitis, Fulminant hepatitis |
| Full text: | Texto completo (Ver PDF) |
