| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000412230 |
| ISSN: | 0001-3765 |
| Authors: | Victor, Mauricio M1 David, Jorge M1 Sakukuma, Maria C.K1 Costa-Lotufo, Leticia V2 Moura, Andrea F2 Araujo, Ana J2 |
| Institutions: | 1Universidade Federal da Bahia, Instituto de Quimica, Salvador, Bahia. Brasil 2Universidade Federal do Ceara, Centro de Ciencias da Saude, Fortaleza, Ceara. Brasil |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 89 |
| Number: | 3 |
| Pages: | 1369-1380 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity |
| Disciplines: | Química |
| Keyword: | Fitoquímica, Productos naturales, Esteres terpénicos, Modificación química, Actividad antitumoral, Esteroides, Triterpenos |
| Keyword: | Chemistry, Phytochemistry, Natural products, Terpene esters, Chemical modification, Antitumoral activity, Steroids, Triterpenes |
| Full text: | Texto completo (Ver HTML) |
