| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000409003 |
| ISSN: | 0001-3765 |
| Authors: | Monte, Zenaide S1 Silva, Amanda M2 Lima, Glaucia M.S3 Silva, Teresinha G. da3 Marques, Karla M.R3 Rodrigues, Maria D3 Falcao, Emerson P.S4 Melo, Sebastiao J1 |
| Institutions: | 1Universidade Federal de Pernambuco, Departamento de Ciencias Farmaceuticas, Recife, Pernambuco. Brasil 2Universidade Federal de Pernambuco, Departamento de Biomedicina, Recife, Pernambuco. Brasil 3Universidade Federal de Pernambuco, Departamento de Antibioticos, Recife, Pernambuco. Brasil 4Universidade Federal de Pernambuco, Nucleo de Nutricao, Vitoria de Santo Antao, Pernambuco. Brasil |
| Year: | 2017 |
| Season: | Jun |
| Volumen: | 89 |
| Number: | 2 |
| Pages: | 1051-1058 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity |
| Disciplines: | Medicina, Química |
| Keyword: | Química farmacéutica, Arilamidinas, Síntesis química, Actividad antimicrobiana, Citotoxicidad |
| Keyword: | Medicine, Chemistry, Medicinal chemistry, Arylamidines, Chemical synthesis, Antimicrobial activity, Cytotoxicity |
| Full text: | Texto completo (Ver HTML) |
