Journal: | Anais da Academia Brasileira de Ciencias |
Database: | PERIÓDICA |
System number: | 000419765 |
ISSN: | 0001-3765 |
Authors: | Eduardo Canosa, Silvina1 Marco, María1 Sigüeiro, Rita1 Mouriño, Antonio1 |
Institutions: | 1Universidad de Santiago de Compostela, Laboratorio de Investigación Ignacio Ribas, Santiago de Compostela, La Coruña. España |
Year: | 2018 |
Season: | May |
Volumen: | 90 |
Number: | 1 |
Pages: | 1035-1042 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development |
Disciplines: | Medicina, Química |
Keyword: | Química farmacéutica, Vitamina D, Análogos químicos, Síntesis química, Rearreglo sigmatrópico, Anillos aromáticos |
Keyword: | Medicinal chemistry, Vitamin D, Chemical analogues, Chemical synthesis, Sigmatropic rearrangement, Aromatic rings |
Full text: | Texto completo (Ver HTML) |