| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000357094 |
| ISSN: | 0001-3765 |
| Authors: | Cruz, Laura N1 Wu, Yang2 Craig, Alister G2 Garcia, Celia R.S1 |
| Institutions: | 1Universidade de Sao Paulo, Instituto de Biociencias, Sao Paulo. Brasil 2Liverpool School of Tropical Medicine, Liverpool, Lancashire. Reino Unido |
| Year: | 2012 |
| Season: | Jun |
| Volumen: | 84 |
| Number: | 2 |
| Pages: | 555-571 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al. 2011) there is still a relative low investment toward antimalarial drugs. Briefly there are targets classes of antimalarial drugs currently being tested including: kinases, proteases, ion channel of GPCR, nuclear receptor, among others (Gamo et al. 2010). Here we review malaria signal transduction pathways in Red Blood Cells (RBC) as well as infected RBCs and endothelial cells interactions, namely cytoadherence. The last process is thought to play an important role in the pathogenesis of severe malaria. The molecules displayed on the surface of both infected erythrocytes (IE) and vascular endothelial cells (EC) exert themselves as important mediators in cytoadherence, in that they not only induce structural and metabolic changes on both sides, but also trigger multiple signal transduction processes, leading to alteration of gene expression, with the balance between positive and negative regulation determining endothelial pathology during a malaria infection |
| Portuguese abstract | A Malária é responsavel por mais de 1.5 milhões de mortes anualmente, especialmente entre crianças (Snow et al. 2005). Apesar da gravidade da situação e grande esforço para o desenvolvimento de novas drogas (Yuan et al. 2011), os investimentos em drogas antimaláricas ainda é relativamente baixo. Brevemente, os alvos antimaláricos atualmente testados incluem: quinases, proteases, canais iônicos para GPCR, receptores nucleares entre outros (Gamo et al. 2010). No presente trabalho nós revisamos as vias de transdução de sinal em eritrócitos assim como eritrócitos infectados e interações com células endoteliais, denominada citoaderência. Este processo é conhecido por sua importante função na patogenicidade da malária severa. As moléculas expressas na s |
| Disciplines: | Biología, Medicina |
| Keyword: | Parasitología, Microbiología, Paludismo, Transducción de señales, Citoadherencia, Eritrocitos, Plasmodium |
| Keyword: | Biology, Medicine, Parasitology, Microbiology, Malaria, Signal transduction, Cytoadherence, Erythrocytes, Plasmodium |
| Full text: | Texto completo (Ver HTML) |
