| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000412276 |
| ISSN: | 0001-3765 |
| Authors: | Lipinski, Leandro C1 Kmetiuk, Louise B2 Mathias, Paulo C.F3 Malta, Ananda3 Favero, Giovani M2 Ribeiro, Tatiane A3 Toledo, Alceu1 Montemor-Netto, Mario R1 Rodrigues, Marcos R.S1 |
| Institutions: | 1Universidade Estadual de Ponta Grossa, Departamento de Medicina, Ponta Grossa, Parana. Brasil 2Universidade Estadual de Ponta Grossa, Departamento de Ciencias Farmaceuticas, Ponta Grossa, Parana. Brasil 3Universidade Estadual de Maringa, Departamento de Biotecnologia, Genetica e Biologia Celular, Maringa, Parana. Brasil |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 89 |
| Number: | 3 |
| Pages: | 1699-1706 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium behavior. This macromolecule promotes positive effects on laboratorial metabolic parameters and decreases diabetic intestinal hypertrophy. This study aims to test if oral insulin can influence metabolic parameters and intestinal weight in obese non-diabetic rats. Methods: Twelve weeks old Wistar rats were divided in 3 groups: control (CTRL) standard chow group; high fat diet low carbohydrates group (HFD) and HFD plus daily oral 20U insulin gavage (HFD+INS). Weight and food consumption were weekly obtained. After eight weeks, fasting blood samples were collected for laboratorial analysis. After euthanasia gut samples were isolated. Results: Rat oral insulin treatment decreased body weight gain (p<0,001), fasting glucose and triglycerides serum levels (p<0,05) an increased intestinal weight of distal ileum (P<0,05). Animal submitted to high fat diet presented higher levels of HOMA-IR although significant difference to CT was not achieved. HOMA-beta were significantly higher (p<0.05) in HFD+INS. Visceral fat was 10% lower in HFD+INS but the difference was not significant. Conclusions: In non-diabetic obese rats, oral insulin improves metabolic malfunction associated to rescue of beta-cell activity |
| Disciplines: | Medicina |
| Keyword: | Endocrinología, Medicina experimental, Obesidad, Insulina, Grasas, Modelos animales, Células beta, Páncreas, Ratas |
| Keyword: | Medicine, Endocrinology, Experimental medicine, Obesity, Insulin, Fat, Animal models, Beta cells, Pancreas, Rats |
| Full text: | Texto completo (Ver HTML) |
