| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000418006 |
| ISSN: | 0001-3765 |
| Authors: | Gómez Cansino, Rocío1 Guzmán Gutiérrez, Silvia Laura2 Campos Lara, María Guadalupe3 Espitia Pinzón, Clara Inés2 Reyes Chilpa, Ricardo1 |
| Institutions: | 1Universidad Nacional Autónoma de México, Instituto de Química, Ciudad de México. México 2Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México 3Hospital Infantil de México "Federico Gómez", Ciudad de México. México |
| Year: | 2017 |
| Season: | Mar |
| Volumen: | 89 |
| Number: | 1 |
| Pages: | 31-44 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/mL). Other potent extracts (inhibition > 95%, 50 µg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identified, the most potent are: Licarin A (isolated from A. taliscana), and 9-amino-9-methoxy-3,4-dihydro-2H-benzo[h]-chromen-2-one (transformation product of 9-methoxytariacuripyrone isolated from Aristolochia brevipes), both with MIC= 3.125 µg/mL, that is 8-fold less potent than the reference drug Rifampicin (MIC= 0.5 µg/mL). Any of the compounds or extracts here reviewed has been studied in clinical trials or with animal models; however, these should be accomplished since several are active against strains resistant to common drugs |
| Disciplines: | Química, Medicina |
| Keyword: | Fitoquímica, Farmacología, Plantas medicinales, Productos naturales, Actividad antibacteriana, Tuberculosis, Mycobacterium tuberculosis |
| Keyword: | Phytochemistry, Pharmacology, Medicinal plants, Natural products, Antibacterial activity, Tuberculosis, Mycobacterium tuberculosis |
| Full text: | Texto completo (Ver HTML) |
