| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000419771 |
| ISSN: | 0001-3765 |
| Authors: | Souza, Juliana M. De1 Galaverna, Renan2 Souza, Aline A.N. de1 Brocksom, Timothy J1 Pastre, Julio C2 Souza, Rodrigo O.M.A. de3 Oliveira, Kleber T. de1 |
| Institutions: | 1Universidade Federal de Sao Carlos, Departamento de Quimica, Sao Carlos, Sao Paulo. Brasil 2Universidade Estadual de Campinas, Instituto de Quimica, Campinas, Sao Paulo. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Quimica, Rio de Janeiro. Brasil |
| Year: | 2018 |
| Season: | May |
| Volumen: | 90 |
| Number: | 1 |
| Pages: | 1131-1174 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs |
| Disciplines: | Medicina, Química |
| Keyword: | Química farmacéutica, Productos naturales, Compuestos bioactivos, Síntesis química, Química de fluídos |
| Keyword: | Medicinal chemistry, Natural products, Bioactive compounds, Chemical synthesis, Continuous flow chemistry |
| Full text: | Texto completo (Ver HTML) |
