| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000424391 |
| ISSN: | 0001-3765 |
| Authors: | Luyen, Nguyen Thi1 Dang, Nguyen Hai2 Binh, Phung Thi Xuan3 Hai, Nguyen Thi4 Dat, Nguyen Tien1 |
| Institutions: | 1Vietnam Academy of Science and Technology, Center for Research and Technology Transfer, Hanoi. Vietnam 2Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hanoi. Vietnam 3Electric Power University, Hanoi. Vietnam 4Tan Trao University, Faculty of Natural Science and Technology, Tuyen Quang, Yen Son. Vietnam |
| Year: | 2018 |
| Season: | Sep |
| Volumen: | 90 |
| Number: | 3 |
| Pages: | 2881-2886 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This paper evaluated the inhibitory effect of 3-O-[β-d-glucopyranosyl-(1→4)-β-d-glucuronopyranosyl] oleanolic acid 28-O-β-d-glucopyranosyl ester (PFS), a major saponin isolated from Polyscias fruticosa leaves, on α-amylase and α-glucosidase, and its potential for reducing the postprandial blood glucose level in mice. In enzyme inhibition assays, PFS strongly inhibited porcine pancreas α-amylase and yeast α-glucosidase. Using the Lineweaver–Burk equation, we found that PFS inhibited porcine pancreas α-amylase in a mixed noncompetitive mode, and yeast α-glucosidase via noncompetitive inhibition. In the sucrose tolerance test, PFS at 100 mg/kg body weight significantly decreased the postprandial blood glucose level in mice fed a high-sucrose diet. These findings suggest that P. fruticosa leaves and their major saponin PFS can be used to prevent and treat diabetes and its complications |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Farmacología, Saponinas, Actividad hipoglicémica, Alfa amilasa, Alfa-glucosidasa, Polyscias fruticosa, Araliaceae |
| Keyword: | Phytochemistry, Pharmacology, Saponins, Hypoglycemic activity, Alpha-amylase, Alpha-glycosidase, Polyscias fruticosa, Araliaceae |
| Full text: | Texto completo (Ver HTML) |
