| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435786 |
| ISSN: | 0001-3765 |
| Authors: | Fernandes, Denilsa P1 Pimentel, Muriel M.L1 Santos, Fernanda A. dos1 Praxedes, Erika A1 Brito, Parmenedes D. de1 Lima, Mikael A1 Lelis, Ivana C.N.G1 Macedo, Michelly F. de1 Bezerra, Marcelo B1 |
| Institutions: | 1Universidade Federal Rural do Semi-Arido, Departamento de Ciencias Animais, Mossoro, Rio Grande do Norte. Brasil |
| Year: | 2018 |
| Season: | Dic |
| Volumen: | 90 |
| Number: | 4 |
| Pages: | 3941-3948 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Hematological and biochemical profile studies help to evaluate functional changes of animals used in experiments. The aim of this study was to determine the hematological and biochemical profile of immunosuppressed BALB/c nude and C57BL/6 SCID mice after bovine ovarian xenotransplantation. Therefore, a total of 74 female mice were divided into four groups: non-xenotransplanted animals, xenotransplanted animals, xenotransplanted animals treated with eCG and xenotransplanted animals treated with FSH + LH. After anesthesia, blood samples were collected and hematologic and biochemical values were evaluated. The results showed no significant differences (p ≤ 0.05) for hematological parameters between the control group and the treatment groups of both strains. However, considering the biochemical profile, it was observed an increase of AST concentrations (p ≤ 0.05) in both strains and a decrease of ALT concentrations (p ≤ 0.05) only in C57BL/6 SCID strain of the groups subjected to hormonal treatment compared with those non subjected. Additionally, the values of the renal enzymes, urea and creatinine, did not differ (p ≤ 0.05) between the groups. Our findings suggest that the xenotransplantation procedure as well as the hormonal dosages had no significant effect on the well-being of the animals considering the evaluated hematological and biochemical profile |
| Disciplines: | Biología |
| Keyword: | Mamíferos, Inmunología, Ratones, Inmunosupresión, Perfil hematológico, Perfil bioquímico |
| Keyword: | Mammals, Immunology, Mice, Immunosuppression, Hematological profile, Biochemical profile |
| Full text: | https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000703941&lng=es&nrm=iso&tlng=en |
