Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
Document title: Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000417631
ISSN: 0001-3765
Authors: 1
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Institutions: 1Universidade Federal de Juiz de Fora, Centro de Biologia da Reproducao, Juiz de Fora, Minas Gerais. Brasil
2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina Veterinaria de Aracatuba, Aracatuba, Sao Paulo. Brasil
3Universidade Federal de Juiz de Fora, Faculdade de Medicina, Juiz de Fora, Minas Gerais. Brasil
Year:
Season: Dic
Volumen: 89
Number: 4
Pages: 2833-2842
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry
Disciplines: Medicina
Keyword: Farmacología,
Fitoquímica,
Bioensayos,
Extractos vegetales,
Ginkgo biloba,
Ginkgoaceae,
Osteoporosis,
Densidad mineral ósea
Keyword: Pharmacology,
Phytochemistry,
Bioassays,
Plant extracts,
Ginkgo biloba,
Ginkgoaceae,
Osteoporosis,
Bone mineral density
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