| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000436061 |
| ISSN: | 0001-3765 |
| Authors: | Vogas, Rityello S1 Pereira, Mariana T.M1 Duarte, Luiza S2 Carneiro, Mara J3 Farsura, Andrew F2 Machado, Joao Augusto M.M1 Costa, Ingrid F4 Tomé, Mayara R.N4 Milton, Flora A5 Neves, Francisco A.R6 Andreo, Marcio Adriano4 Lopez, Begoña Gimenez-Cassina7 Sawaya, Alexandra Christine Helena F3 Pascoal, Vinicius D’Avila Bitencourt1 Pascoal, Aislan Cristina R.F1 |
| Institutions: | 1Universidade Federal Fluminense, Instituto de Biologia, Niteroi, Rio de Janeiro. Brasil 2Universidade Federal Fluminense, Instituto de Saude de Nova Friburgo, Nova Friburgo, Rio de Janeiro. Brasil 3Universidade Estadual de Campinas, Instituto de Biologia, Campinas, Sao Paulo. Brasil 4Universidade Federal de Sao Paulo, Departamento de Ciencias Farmaceuticas, Diadema, Sao Paulo. Brasil 5Universidade de Brasilia, Faculdade de Medicina, Brasilia, Distrito Federal. Brasil 6Universidade de Brasilia, Faculdade de Ciencias de Saude, Brasilia, Distrito Federal. Brasil 7Harvard Medical School, Department of Neurosurgery, Boston, Massachusetts. Estados Unidos de América |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 2 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Solidago microglossa is used as an anti-inflammatory agent in traditional Brazilian medicine, and this work evaluated the anti-inflammatory potential of the crude ethanolic extract of the flowers of S. microglossa in vivo, as assayed by paw edema models induced by carrageenan, prostaglandin E2, bradykinin and compound 48/80. In the chemical profile, we identified compounds by electrospray ionization mass spectrometry and quantified them by HPLC-DAD. Additionally, this study analyzed the potential to activate the in vitro transcriptional activity of PPARγ, which is a nuclear receptor linked to the anti-inflammatory response. It was possible to identify five compounds: quinic acid, quercetin, chlorogenic acid, hyperoside, and rutin. In the paw edema evaluation, it was possible to show the potential of reducing edema during the inflammatory process. The crude ethanolic extract of the flowers of S. microglossa activated PPARγ compared to the full agonist rosiglitazone and in a dose-response manner. It is possible to conclude that the extract of the flowers of S. microglossa showed anti-inflammatory activity, and the phenolic compounds present in this species might be responsible for this activity |
| Disciplines: | Medicina, Química |
| Keyword: | Fitoquímica, Farmacología, Plantas medicinales, Actividad antiinflamatoria, Compuestos fenólicos, Solidago microglossa, Asteraceae |
| Keyword: | Phytochemistry, Pharmacology, Medicinal plants, Antiinflammatory activity, Phenolic compounds, Solidago microglossa, Asteraceae |
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