| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000418094 |
| ISSN: | 0001-3765 |
| Authors: | Pereira, Joquebede R1 Queiroz, Raphael F2 Siqueira, Erlania A. de3 Brasileiro-Vidal, Ana Christina3 Sant'Ana, Antonio E.G4 Affonso, Paulo R.A. de Mello5 Silva, Daniel M1 |
| Institutions: | 1Universidade Estadual do Sudoeste da Bahia, Departamento de Quimica e Exatas, Jequie, Bahia. Brasil 2Universidade Estadual do Sudoeste da Bahia, Departamento de Ciencias Naturais, Vitoria da Conquista, Bahia. Brasil 3Universidade Federal de Pernambuco, Departamento de Genetica, Recife, Pernambuco. Brasil 4Universidade Federal de Alagoas, Instituto de Quimica e Biotecnologia, Maceio, Alagoas. Brasil 5Universidade Estadual do Sudoeste da Bahia, Departamento de Ciencias Biologicas, Jequie, Bahia. Brasil |
| Year: | 2017 |
| Season: | Mar |
| Volumen: | 89 |
| Number: | 1 |
| Pages: | 317-332 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotective and hypoglycemiant effects of raw extract, fractions and compounds from leaves of M. hirsuta. The cytogenotoxic effects of ursolic and oleanolic acids, the main phytotherapic components of this plant, were assessed. The raw extract and fractions presented steroids, saponins, flavonols, flavanonols, flavanones, xanthones, phenols, tannins, anthocyanins, anthocyanidins and flavonoids. The ethyl acetate fraction inhibited efficiently the cascade of lipid peroxidation while the hydroalcoholic fraction was richer in total phenols and more efficient in capturing 2,2-diphenyl-1-picrylhydrazyl (·DPPH) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS·+) radicals. The isolated fraction of M. hirsuta also inhibited the α-amylase activity. Cytotoxic effects were absent in both raw extract and fractions while ursolic+oleanolic acids were efficient in protecting cells after exposure to hydrogen peroxide. Moreover, this mixture of acid shad no significant interference on the mitotic index and frequency of nuclear and/or chromosomal abnormalities in Allium cepa test. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and oxidative pathologies, including diabetes |
| Disciplines: | Biología, Química |
| Keyword: | Angiospermas, Fitoquímica, Farmacología, Actividad antioxidante, Citotoxicidad, Hipoglucemiantes, Mansoa hirsuta, Bignoniaceae |
| Keyword: | Angiosperms, Phytochemistry, Pharmacology, Antioxidant activity, Cytotoxicity, Hypoglycemic agents, Mansoa hirsuta, Bignoniaceae |
| Full text: | Texto completo (Ver HTML) |
