Dextran Sulphate of Sodium-induced colitis in mice: antihyperalgesic effects of ethanolic extract of Citrus reticulata and potential damage to the central nervous system
Document title: Dextran Sulphate of Sodium-induced colitis in mice: antihyperalgesic effects of ethanolic extract of Citrus reticulata and potential damage to the central nervous system
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000424440
ISSN: 0001-3765
Authors: 1
2
2
1
1
1
3
1
1
1
1
1
Institutions: 1Universidade do Sul de Santa Catarina, Programa de Pos-graduacao em Ciencias da Saude, Palhoca, Santa Catarina. Brasil
2Universidade do Sul de Santa Catarina, Laboratorio de Neurociencia Experimental, Palhoca, Santa Catarina. Brasil
3Universidade do Sul de Santa Catarina, Programa de Pos-graduacao em Ciencias Ambientais, Palhoca, Santa Catarina. Brasil
Year:
Season: Sep
Volumen: 90
Number: 3
Pages: 3139-3146
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Citrus species are widely related to antihyperalgesic and anti-inflammatory effects. The aim of this study was to investigate if treatment with ethanolic extract from peels of mature Citrus reticulata Blanco causes antihyperalgesic effects on the referred mechanical hyperalgesia in a model of dextran sulphate of sodium (DSS)-induced colitis in mice, as well as the possible oxidative damage in different regions of the brain induced by its inflammatory reaction. Antihyperalgesia (30 to 300 mg/kg) was investigated by behavioral response (frequency of response to von Frey filament stimulation) in Swiss mice, while damage to central nervous system was investigated through techniques that evaluated oxidative stress using male black C57 BL6 mice (n=8). Treatment of the animals with the extract (100 mg/kg) from days 3 to 5 after colitis induction reduced referred the mechanical hyperalgesia (32.6 ± 5.1) in relation to the control group (57.4 ± 2.0). Levels of lipid peroxidation or carbonyl proteins were augmented in colitis-induced animals in relation to the disease group. These results indicated an antihyperalgesic effect of the studied extract and a potential impairment of the central nervous system functioning caused by inflammation during colitis, which could be related to mental disorders observed in patients suffering of this pathology
Disciplines: Medicina,
Química
Keyword: Medicina experimental,
Farmacología,
Gastroenterología,
Plantas medicinales,
Extractos vegetales,
Citrus reticulata,
Hiperalgesia,
Colitis,
Modelos animales
Keyword: Experimental medicine,
Pharmacology,
Gastroenterology,
Medicinal plants,
Plant extracts,
Citrus reticulata,
Hyperalgesia,
Colitis,
Animal models
Full text: Texto completo (Ver HTML)