| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000412267 |
| ISSN: | 0001-3765 |
| Authors: | Silva, Eduardo R. da1 Bizzo, Humberto R2 Fernandes, Patricia D3 Veiga-Junior, Valdir F. da4 Leitao, Suzana G1 Oliveira, Danilo R. de1 |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Faculdade de Farmacia, Rio de Janeiro. Brasil 2Empresa Brasileira de Pesquisa Agropecuaria, Agroindustria de Alimentos, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Ciencias Biomedicas, Rio de Janeiro. Brasil 4Universidade Federal do Amazonas, Departamento de Quimica, Manaus, Amazonas. Brasil |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 89 |
| Number: | 3 |
| Pages: | 1643-1654 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization. Thus, pharmacological and toxicological evaluation accessed by an apparatus specifically designed and validated for this type of administration is extremely important. Based on pre-existing models, an inhalation chamber was developed. This presents a central structure with five animal holders. The nebulized air passes directly and continuously through these holders and subsequently to an outlet. Evaluation of its operation was performed using clove essential oil, a nebulizer, and a flow meter. The air within the chamber was collected by static headspace and analyzed by gas chromatography with a flame ionization detector. For this purpose, a 2.5 minutes chromatographic method was developed. The air flow in each of the five outputs was 0.92 liters per minute. During the first minute, the chamber became saturated with the nebulized material. Homogeneous and continuous operation of the chamber was observed without accumulation of volatile material inside it for 25 minutes. The inhalation chamber works satisfactorily for in vivo tests with medicines designed to be administrated by inhalation |
| Disciplines: | Medicina, Química |
| Keyword: | Farmacología, Química farmacéutica, Pruebas farmacológicas, Eficacia terapéutica, Actividad biológica, Cámaras de inhalación, Cromatografía de gases, Syzygium aromaticum |
| Keyword: | Medicine, Chemistry, Pharmacology, Medicinal chemistry, Pharmacological tests, Therapeutic efficacy, Biological activity, Inhalation chambers, Gas chromatography, Syzygium aromaticum |
| Full text: | Texto completo (Ver HTML) |
