| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000419776 |
| ISSN: | 0001-3765 |
| Authors: | Pinheiro, Luiz C.S1 Feitosa, Lívia M1 Silveira, Flávia F. da1 Boechat, Nubia1 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos, Rio de Janeiro. Brasil |
| Year: | 2018 |
| Season: | May |
| Volumen: | 90 |
| Number: | 1 |
| Pages: | 1251-1272 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria |
| Disciplines: | Medicina, Química |
| Keyword: | Química farmacéutica, Paludismo, Diseño de fármacos, Artemisinina, Derivados semi-sintéticos |
| Keyword: | Medicinal chemistry, Malaria, Drug design, Artemisinine, Semi-synthetic derivatives |
| Full text: | Texto completo (Ver HTML) |
