| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000417630 |
| ISSN: | 0001-3765 |
| Authors: | Goncalves, Regiane1 Ayres, Vanessa F.S1 Carvalho, Carlos E1 Souza, Maria G.M2 Guimaraes, Anderson C1 Crotti, Antonio E.M4 Correa, Geone M1 Martins, Carlos H.G2 Takeara, Renata1 Silva, Eliane O3 |
| Institutions: | 1Universidade Federal do Amazonas, Instituto de Ciencias Exatas e Tecnologicas, Itacoatiara, Amazonas. Brasil 2Universidade de Franca, Nucleo de Pesquisas em Ciencias Exatas e Tecnologicas, Franca, Sao Paulo. Brasil 3Universidade Federal da Bahia, Instituto de Quimica, Salvador, Bahia. Brasil 4Universidade de Sao Paulo, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Year: | 2017 |
| Season: | Dic |
| Volumen: | 89 |
| Number: | 4 |
| Pages: | 2825-2832 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Abnormal multiplication of oral bacteria causes dental caries and dental plaque. These diseases continue to be major public health concerns worldwide, mainly in developing countries. In this study, the chemical composition and antimicrobial activity of the essential oil of Vitex agnus-castus leaves (VAC‒EO) collected in the North of Brazil against a representative panel of cariogenic bacteria were investigated. The antimicrobial activity of VAC-EO was evaluated in terms of its minimum inhibitory concentration (MIC) values by using the broth microdilution method in 96-well microplates. The chemical constituents of VAC-EO were identified by gas chromatography (GC‒FID) and gas chromatography‒mass spectrometry (GC‒MS). VAC‒EO displayed some activity against all the investigated oral pathogens; MIC values ranged from 15.6 to 200 μg/mL. VAC-EO had promising activity against Streptococcus mutans (MIC= 15.6 μg/mL), Lactobacillus casei (MIC= 15.6 μg/mL), and Streptococcus mitis (MIC= 31.2 μg/mL). The compounds 1,8-cineole (23.8%), (E)-β-farnesene (14.6%), (E)-caryophyllene (12.5%), sabinene (11.4%), and α-terpinyl acetate (7.7%) were the major chemical constituents of VAC‒EO. VAC-EO displays antimicrobial activity against cariogenic bacteria. The efficacy of VAC-EO against S. mutans is noteworthy and should be further investigated |
| Disciplines: | Medicina, Química |
| Keyword: | Fitoquímica, Farmacología, Angiospermas, Aceites esenciales, Actividad antibacteriana, Patógenos orales, Bacterias cariogénicas, Vitex agnus-castus, Lamiaceae |
| Keyword: | Phytochemistry, Pharmacology, Angiosperms, Essential oils, Antbacterial activity, Oral pathogens, Cariogenic bacteria, Vitex agnus-castus, Lamiaceae |
| Full text: | Texto completo (Ver HTML) |
