Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives



Document title: Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000419763
ISSN: 0001-3765
Authors: 1
1
1
Institutions: 1Universidade de Aveiro, Departamento de Quimica, Aveiro. Brasil
Year:
Season: May
Volumen: 90
Number: 1
Pages: 993-1026
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its alkyl esters). Oncological, dermatological and ophthalmic applications are now taking place for the benefit of mankind. The second part of this review is related with the work carried out in Aveiro at the authors University on the synthesis and biological evaluation of several potential PDT photosensitizers. Not only new synthetic methodologies mainly for porphyrins and chlorins were developed but also other related macrocycles of the phthalocyanine and corrole types have entered in the same “pipeline”. In vivo and in vitro biological evaluations also took place under interdisciplinary studies
Disciplines: Medicina,
Química
Keyword: Química farmacéutica,
Oncología,
Terapéutica y rehabilitación,
Cáncer,
Terapia fotodinámica,
Porfirinas,
Clorinas,
Fotosensibilizadores
Keyword: Medicinal chemistry,
Oncology,
Therapeutics and rehabilitation,
Cancer,
Photodynamic therapy,
Photosensitizers,
Porphyrins,
Chlorins
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