Biomarkers as predictors of mortality in critically ill patients with solid tumors



Document title: Biomarkers as predictors of mortality in critically ill patients with solid tumors
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000417689
ISSN: 0001-3765
Authors: 1
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Institutions: 1Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Season: Dic
Volumen: 89
Number: 4
Pages: 2921-2930
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study. Serum biochemical markers obtained in the first 24 hours of Intensive Care Unit hospitalization were analyzed. A second review of medical records occurred after three months objected to identify death or Unit discharged. A sample of 130 individuals was obtained (control group n = 65, study group n = 65). In the multivariate model, serum magnesium values ​​OR = 3.97 (1.17; 13.5), presence of neoplasia OR = 2.68 (95% CI 1.13; 6.37) and absence of sepsis OR = 0.31 (95% CI 0.12; 0.79) were robust predictors of mortality. The association of solid tumors, sepsis presence and alteration in serum magnesium levels resulted in an increased chance of mortality in critically ill patients
Disciplines: Medicina
Keyword: Oncología,
Diagnóstico,
Tumores,
Marcadores bioquímicos,
Mortalidad,
Pacientes críticos
Keyword: Oncology,
Diagnosis,
Tumors,
Biochemical markers,
Mortality,
Critically ill patients
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