| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000435876 |
| ISSN: | 0001-3765 |
| Authors: | Thanaraj, Mrunalini1 Rathanasamy, Rajasekar2 Jeganathan, Prakash M3 |
| Institutions: | 1Kongu Engineering College, Department of Electronics and Instrumentation Engineering, Erode, Tamil Nadu. India 2Kongu Engineering College, Department of Mechanical Engineering, Erode, Tamil Nadu. India 3Periyar University, Department of Food Science and Nutrition, Salem, Tamil Nadu. India |
| Year: | 2020 |
| Volumen: | 92 |
| Number: | 3 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The major impact in the clinical field is the harm posed by cancer. One most common type of cancer occurs in the skin. Though the conventionally existing modalities are successful in some cases, there is a need for new sensible methods to detect tumors at their initial stage. In accordance to these reasons and in addition to the incapability of the drugs to cross cellular barriers in skin the conventional administration methods are often compromised. To eradicate these problems the research work aims to develop the electrical analogue of skin involving layers like dermis, subcutaneous tissues, bones and muscular layers. The mathematical model has been developed to determine the electrical network of skin. The response of different skin layers are analyzed through simulation studies. It is observed that the cells present in each layer absorbs some amount of drug and let out the remaining to the neighboring layers. Further to minimize the diffusion rate of the drug a conventional controller has been incorporated and the results are analyzed by the contrast of the absorption and diffusion capacities for different layers of skin |
| Disciplines: | Medicina, Ingeniería, Química |
| Keyword: | Química farmacéutica, Oncología, Dermatología, Cáncer de piel, Liberación de fármacos, Tasa de absorción, Tasa de difusión, Análogos eléctricos, Modelos matemáticos |
| Keyword: | Medicinal chemistry, Oncology, Dermatology, Absorption rate, Diffusion rate, Drug delivery, Electrical analogues, Mathematical models, Skin cancer |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
