| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000417629 |
| ISSN: | 0001-3765 |
| Authors: | Pereira, Flaviane G1 Marquete, Ronaldo2 Domingos, Levy T3 Rocha, Marco E.N4 Ferreira-Pereira, Antonio3 Mansur, Elisabeth5 Moreira, Davyson L4 |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro. Brasil 2Fundacao Instituto Brasileiro de Geografia e Estatistica, Diretoria de Geociencias, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Microbiologia "Paulo de Goes", Rio de Janeiro. Brasil 4Fundacao Oswaldo Cruz, Instituto de Tecnologia de Farmacos, Rio de Janeiro. Brasil 5Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro. Brasil |
| Year: | 2017 |
| Season: | Dic |
| Volumen: | 89 |
| Number: | 4 |
| Pages: | 2817-2824 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Casearia genus (Salicaceae) is found in sub-tropical and tropical regions of the world and comprises about 160-200 species. It is a medicinal plant used in South America, also known as “guaçatonga”, “erva-de-tiú”, “cafezinho-do-mato”. In Brazil, there are about 48 species and 12 are registered in the State of Rio de Janeiro, including Casearia sylvestris Sw. There are many studies related to the chemical profile and cytotoxic activities of extracts from these plants, although few studies about the antifungal potential of the essential oil have been reported. In this work, we have studied the antifungal properties of the essential oil of C. sylvestris leaves, as well as of their fractions, against four yeasts (Saccharomyces cerevisae, Candida albicans, C. glabrata and C. krusei) for the first time. The chemical analysis of the essential oil revealed a very diversified (n = 21 compounds) volatile fraction composed mainly of non-oxygenated sesquiterpenes (72.1%). These sesquiterpenes included α-humulene (17.8%) and α-copaene (8.5%) and the oxygenated sesquiterpene spathulenol (11.8%) were also identified. Monoterpenes were not identified. The fractions are mainly composed of oxygenated sesquiterpenes, and the most active fraction is rich in the sesquiterpene 14-hydroxy -9-epi-β-caryophyllene. This fraction was the most effective in inhibiting the growth of three yeast strains |
| Disciplines: | Medicina, Química |
| Keyword: | Fitoquímica, Farmacología, Angiospermas, Aceites esenciales, Actividad antifúngica, Sesquiterpenos, Casearia sylvestris, Salicaceae |
| Keyword: | Phytochemistry, Pharmacology, Angiosperms, Essential oils, Antifungal activity, Sesquiterpenes, Casearia sylvestris, Salicaceae |
| Full text: | Texto completo (Ver HTML) |
