| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000412252 |
| ISSN: | 0001-3765 |
| Authors: | Silva, Fernando C1 Rodrigues, Vanessa G2 Duarte, Lucienir P2 Lula, Ivana S2 Sinisterra, Ruben D2 Vieira-Filho, Sidney A3 Rodrigues, Rodrigo A.L4 Kroon, Erna G4 Oliveira, Patricia L4 Farias, Luiz M4 Magalhaes, Paula P4 Silva, Gracia D.F2 |
| Institutions: | 1Universidade do Estado de Minas Gerais, Departamento das Licenciaturas, Divinopolis, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Ouro Preto, Escola de Farmacia, Ouro Preto, Minas Gerais. Brasil 4Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 89 |
| Number: | 3 |
| Pages: | 1555-1564 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising |
| Disciplines: | Biología, Medicina |
| Keyword: | Farmacología, Plantas medicinales, Extractos vegetales, Actividad antiviral, Virus del dengue, Diarrea, Triterpenos pentacíclicos, Maytenus gonoclada, Celastraceae |
| Keyword: | Biology, Medicine, Pharmacology, Medicinal plants, Plant extracts, Antiviral activity, Dengue virus, Diarrhea, Pentacyclic triterpenes, Maytenus gonoclada, Celastraceae |
| Full text: | Texto completo (Ver HTML) |
