| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000417610 |
| ISSN: | 0001-3765 |
| Authors: | Hou, Chun1 Miao, Yong2 Ji, Hang1 Wang, Susheng1 Liang, Gang1 Zhang, Zhihua1 Hong, Weijin2 |
| Institutions: | 1The First Affiliated Hospital of Guangzhou Medical University, Department of Plastic and Cosmetic Surgery, Guangzhou, Guangdong. China 2Southern Medical University, Nanfang Hospital, Guangzhou, Guangdong. China |
| Year: | 2017 |
| Season: | Dic |
| Volumen: | 89 |
| Number: | 4 |
| Pages: | 2707-2718 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle |
| Disciplines: | Medicina, Química |
| Keyword: | Dermatología, Farmacología, Fitoquímica, Crecimiento del cabello, Ciclo capilar, 6-gingerol, Gengibre |
| Keyword: | Dermatology, Pharmacology, Phytochemistry, Hair growth, Hair cycle, 6-gingerol, Ginger |
| Full text: | Texto completo (Ver HTML) |
