| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000410421 |
| ISSN: | 0365-0596 |
| Autores: | Su, Fang1 Xiao, Weiguo2 Yang, Pingting2 Chen, Qingyan1 Sun, Xiaojie1 Li, Tienan1 |
| Instituciones: | 1Seventh People's Hospital of Shenyang, Department of Dermatology, Shenyang, Liaoning. China 2China Medical University, First Affiliated Hospital, Shenyang, Liaoning. China |
| Año: | 2017 |
| Periodo: | Jul-Ago |
| Volumen: | 92 |
| Número: | 4 |
| Paginación: | 466-469 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The clinical significance of anti-neutrophil cytoplasmic antibodies in patients with new-onset systemic lupus erythematosus, especially in systemic disease accompanied by interstitial lung disease remains to be elucidated. Objectives: This study was designed to investigate the role of anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythematosus patients. Methods: A hundred and seven patients with new-onset SLE were enrolled. Presence of anti-neutrophil cytoplasmic antibodies in the sera was assessed by indirect immunofluorescence as well as enzyme linked immunosorbent assay against proteinase-3 and myeloperoxidase. Clinical features and laboratory parameters of patients were also recorded. All patients were subjected to chest X-ray, chest high-resolution computed tomography and pulmonary function test. Results: Forty-five systemic lupus erythematosus patients (45/107, 42%) were seropositive for anti-neutrophil cytoplasmic antibodies. Compared with anti-neutrophil cytoplasmic antibodies-negative patients, the anti-neutrophil cytoplasmic antibodies-positive patients had significantly higher incidence of renal involvement, anemia, and Raynaud's phenomenon as well as decreased serum level of complement 3/complement 4 and elevated erythrocyte sedimentation rate. In addition, there was a positive correlation between serum anti-neutrophil cytoplasmic antibodies level and disease activity of systemic lupus erythematosus. Furthermore, prevalence of interstitial lung disease in the anti-neutrophil cytoplasmic antibodies -positive patients (25/45, 55.6%) was obviously higher than that in the anti-neutrophil cytoplasmic antibodies-negative patients (15/62, 24.2%). Study limitations: The sample size was limited and the criteria for screening new-onset systemic lupus erythematosus patients might produce bias. Conclusions: The level of anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythemat |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Inmunología, Lupus eritematoso sistémico, Anticuerpos citoplásmicos antineutrófilos, Enfermedad intersticial pulmonar |
| Keyword: | Medicine, Dermatology, Immunology, Systemic lupus erythematosus, Anti-neutrophil cytoplasmic antibodies, Interstitial lung disease |
| Texto completo: | Texto completo (Ver HTML) |
