| Journal: | Acta cirurgica brasileira |
| Database: | PERIÓDICA |
| System number: | 000286059 |
| ISSN: | 0102-8650 |
| Authors: | Martins, Antonio Carlos Pereira Britto, Sergio Takata, Clecio Suaid, Haylton Jorge Cologna, Adauto Jose Tucci-Junior, Silvio Araujo, Whemberton M |
| Year: | 2002 |
| Volumen: | 17 |
| Pages: | 52-54 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | OBJECTIVE: To investigate the vessel endothelial growth factor (VEGF) as a risk factor in squamous cell carcinoma of the penis (SCCP). METHODS: Forty-seven patients with penile carcinoma were evaluated retrospectively. The mean age and standard deviation were 61.1±11.7 years. All of them were treated by penectomy and those with positive nodes underwent groin lymphadenectomy. Tumor grading was 35 G1 and 12 G2/3. Primary lesion stage was 24 pT1 and 23 pT2-4. Positive inguinal nodes were observed in 15 patients. Selected paraffin embedded sections were submitted to VEGF immunohistochemical analysis by the avidin-biotin-immunoperoxidase method with antigen retrieval. All slides were examined using an automatic analyzer system and the proportion of labeled cells in 10 high magnification power fields (400X) were recorded in a blind analysis. RESULTS: Median (%) labeling index was 2.3 in G1 versus 2.2 in G2/3 tumors (p=0.60), and 4.0 in pT1 versus 1.8 pT2-4 tumors (p=0.10). The respective data for pN0 patients was 2.8 and for pN+ was 2.1 (p=0.20). Survival curves showed no association with patients survival. CONCLUSION: In squamous cell carcinoma of the penis the VEGF immunoexpression has no association with tumor grade or stage, as well as with patient survival |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Nefrología, Carcinoma, Pene, Células escamosas |
| Keyword: | Medicine, Nephrology, Surgery, Carcinoma, Penis, Squamous cells |
| Full text: | Texto completo (Ver HTML) |
