| Journal: | Acta cirurgica brasileira |
| Database: | PERIÓDICA |
| System number: | 000285890 |
| ISSN: | 0102-8650 |
| Authors: | Paran, Haim1 Sivak, Galit Mayo, Ami Freund, Uri Reshef, Tamar Kidron, Dvora |
| Institutions: | 1Tel Aviv University, Tel Aviv. Israel |
| Year: | 2000 |
| Season: | Abr-Jun |
| Volumen: | 15 |
| Number: | 2 |
| Pages: | 00-00 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Early evaluation of the severity of acute pancreatitis requires measurements of many variables. Clinical parameters as well as CT scan have traditionally been used as predictors of severity, and complications. None of them however can predict the outcome early and reliably. Inflammatory cytokines were shown to play an important role in the inflammatory cascade, which occurs early in the course of the disease. The aim of the present study is to evaluate the predictive value of plasma interleukin-6 (IL-6) and interleukin-1 (IL-1) levels in experimental pancreatitis in rats. Methods: Male wistar rats were anesthetized and pancreatitis was induced by intraparenchymal injection of 5% (group 2) and 10% (group 3) sodium taurocholate (TC), resulting in 2 distinct groups of severity. In sham controls (group 1), saline was injected into the pancreas in the same fashion. Blood samples were obtained before and 2, 4, 24, and 96 hours after the induction of pancreatitis and plasma amylase, lipase, LDH, IL-1 and IL-6 levels were measured. Mortality was recorded every 8 hours. Pancreatitis severity was also assessed by histopathology. Results: Four hours after pancreatitis induction, plasma amylase, lipase and LDH levels were markedly increased in the pancreatitis groups. In the sham control group, moderate increases were also observed. No consistent significant difference in amylase, lipase or LDH levels was observed between the groups. At 2 hours from pancreatitis induction, IL-6 levels increased mildly in-groups 1 and 2, and decreas |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Diagnóstico, Pancreatitis aguda, Inflamación, Citocinas, Marcadores |
| Keyword: | Medicine, Diagnosis, Surgery, Acute pancreatitis, Inflammation, Cytokines, Markers |
| Full text: | Texto completo (Ver HTML) |
