Bone mineral content reduction in youth with surgical form of Schistosomiasis mansoni: factors involved in the pathogenesis



Document title: Bone mineral content reduction in youth with surgical form of Schistosomiasis mansoni: factors involved in the pathogenesis
Journal: Acta cirurgica brasileira
Database: PERIÓDICA
System number: 000285974
ISSN: 0102-8650
Authors: 1




Institutions: 1Universidade Federal de Pernambuco, Recife, Pernambuco. Brasil
Year:
Season: Ene-Feb
Volumen: 16
Number: 1
Pages: 56-61
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Caso clínico, analítico
English abstract Thirty two children and adolescents from 14 to 20 years of age, suffering from hepatosplenic schistosomiasis mansoni and bleeding esophageal varicose veins, were evaluated for bone mineral density (BMD), before undergoing medical and surgical treatment. The surgical protocol was splenectomy, autoimplantation of spleen tissue into a pouch of the major omentum and ligature of the left gastric vein. Follow up of these patients’ ranges from one to ten years with a mean of five years. The BMD was measured at the lumbar spine (L2 - L4) through the dual energy absorptionmetry X-ray (DEXA), using a LUNAR DPX-L densitometer. The degree of Symmers´ fibrosis was assessed by semiautomatic hystomorphometry. In eleven patients, the serum magnesium was measured before an intravenous overload of this ion and subsequently after eight and twenty four hours. Urine was collected 24 hours before and 24 hours after the magnesium overload. Deficiency of magnesium was considered when the uptake of this ion was greater than 40%. There was a significant trend of association between the status of bone mineral content and the Symmers´ fibrosis degree (c² = 6.606 R = 0.01017). There was also a moderate agreement between the greater fibrosis densities ( > the mean percentage) and bone mineral deficits. Although the normal bone mineral content was more found among the patients with better hepatic functional reserve, the results did not reach statistical significance. There was a marked magnesium retention (>95%) in one patient who had severe osteoporosis a
Disciplines: Medicina
Keyword: Cirugía,
Metabolismo y nutrición,
Reserva funcional,
Magnesio,
Densitometría ósea,
Densidad mineral ósea,
Esquistosomiasis,
Fibrosis de Symmers,
Histomorfometría,
Hígado
Keyword: Medicine,
Metabolism and nutrition,
Surgery,
Magnesium,
Bone mineral density,
Schistosomiasis,
Symmers fibrosis,
Histomorphometry,
Functional reserve,
Liver,
Bone densitometry
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